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Testosterone therapy for anaemia in maintenance dialysis.维持性透析患者贫血的睾酮治疗
Br Med J. 1971 Jul 24;3(5768):212-5. doi: 10.1136/bmj.3.5768.212.
2
Androgens in the anaemia of chronic renal failure.慢性肾衰竭贫血中的雄激素
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Intramuscular iron replenishment and replacement combined with testosterone enanthate in maintenance hemodialysis anemia: a follow-up of up to 8 years on 16 patients.维持性血液透析贫血患者中肌肉注射铁补充剂和替代疗法联合庚酸睾酮的疗效：16例患者长达8年的随访
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Haemoglobin and serum iron responses to periodic intravenous iron-dextran infusions during maintenance haemodialysis.维持性血液透析期间，血红蛋白和血清铁对周期性静脉注射右旋糖酐铁的反应。
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The effect of oral iron on the anaemia of patients on maintenance haemodialysis.口服铁剂对维持性血液透析患者贫血的影响。
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Testosterone Deficiency as One of the Major Endocrine Disorders in Chronic Kidney Disease.睾酮缺乏症是慢性肾脏病的主要内分泌紊乱之一。
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Improvement of anaemia in haemodialysed patients after viral or toxic hepatic cytolysis.病毒或毒性肝细胞溶解后血液透析患者贫血情况的改善
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10
Androgen therapy for anemia in renal failure.雄激素疗法治疗肾衰竭贫血
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本文引用的文献

1
Testosterone-induced remission in aplastic anemia of both acquired and congenital types. Further observations in 24 cases.睾酮诱导获得性和先天性再生障碍性贫血缓解。24例进一步观察。
N Engl J Med. 1961 May 11;264:953-67. doi: 10.1056/NEJM196105112641901.
2
Mechanism of testosterone action in erythropoiesis.睾酮在红细胞生成中的作用机制。
Nature. 1965 Apr 17;206(981):270-2. doi: 10.1038/206270a0.
3
Idiopathic aplastic anaemia in children. Results of androgen treatment.
Acta Paediatr Scand. 1969 Jan;58(1):10-4. doi: 10.1111/j.1651-2227.1969.tb04323.x.
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Iron absorption in chronic renal disease.
Clin Sci. 1970 Feb;38(2):191-6. doi: 10.1042/cs0380191.
5
The erythropoietic-stimulating effects of androgens.雄激素对红细胞生成的刺激作用。
Ann N Y Acad Sci. 1968 Mar 29;149(1):356-65. doi: 10.1111/j.1749-6632.1968.tb15169.x.
6
Androgen actions on erythropoiesis.雄激素对红细胞生成的作用。
Ann N Y Acad Sci. 1968 Mar 29;149(1):318-35. doi: 10.1111/j.1749-6632.1968.tb15167.x.

维持性透析患者贫血的睾酮治疗

Testosterone therapy for anaemia in maintenance dialysis.

作者信息

Shaldon S, Koch K M, Oppermann F, Patyna W D, Schoeppe W

出版信息

Br Med J. 1971 Jul 24;3(5768):212-5. doi: 10.1136/bmj.3.5768.212.

DOI:10.1136/bmj.3.5768.212
PMID:5559043
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1798542/
Abstract

Intramuscular testosterone 250-500 mg weekly given to 25 patients on long-term haemodialysis produced a significant rise in haemoglobin level in all patients. The response was reversible when the drug was stopped. Treatment was effective in bilaterally nephrectomized patients and those with intact kidney tissue. The use of intramuscular testosterone is recommended for all adult patients on long-term haemodialysis in order to eliminate the need for routine blood transfusions.

摘要

对25例长期血液透析患者每周肌肉注射250 - 500毫克睾酮，所有患者的血红蛋白水平均显著升高。停药后反应可逆。该治疗方法对双侧肾切除患者和肾组织完整的患者均有效。建议对所有长期血液透析的成年患者使用肌肉注射睾酮，以避免常规输血的需要。