Arnaud Sara B, Navidi Meena, Deftos Leonard, Thierry-Palmer Myrtle, Dotsenko Rita, Bigbee Allison, Grindeland Richard E
National Aeronautics and Space Administration Ames Research Center, Moffett Field, California 94035-1000, USA.
Am J Physiol Endocrinol Metab. 2002 Mar;282(3):E514-21. doi: 10.1152/ajpendo.00299.2001.
The calcium endocrine system of nonhuman primates can be influenced by chairing for safety and the weightless environment of spaceflight. The serum of two rhesus monkeys flown on the Bion 11 mission was assayed pre- and postflight for vitamin D metabolites, parathyroid hormone, calcitonin, parameters of calcium homeostasis, cortisol, and indexes of renal function. Results were compared with the same measures from five monkeys before and after chairing for a flight simulation study. Concentrations of 1,25-dihydroxyvitamin D were 72% lower after the flight than before, and more than after chairing on the ground (57%, P < 0.05). Decreases in parathyroid hormone did not reach significance. Calcitonin showed modest decreases postflight (P < 0.02). Overall, effects of spaceflight on the calcium endocrine system were similar to the effects of chairing on the ground, but were more pronounced. Reduced intestinal calcium absorption, losses in body weight, increases in cortisol, and higher postflight blood urea nitrogen were the changes in flight monkeys that distinguished them from the flight simulation study animals.
非人类灵长类动物的钙内分泌系统会受到为保障安全而进行的模拟失重环境（如乘坐椅子模拟）以及太空飞行失重环境的影响。对搭乘“生物11号”任务的两只恒河猴在飞行前后的血清进行了检测，分析了维生素D代谢物、甲状旁腺激素、降钙素、钙稳态参数、皮质醇和肾功能指标。将结果与五只猴子在进行模拟飞行的椅子试验前后的相同测量值进行了比较。飞行后1,25 - 二羟基维生素D的浓度比飞行前降低了72%，且比地面模拟失重（降低57%，P < 0.05）后更低。甲状旁腺激素的降低未达到显著水平。降钙素在飞行后有适度降低（P < 0.02）。总体而言，太空飞行对钙内分泌系统的影响与地面模拟失重的影响相似，但更为明显。飞行猴子肠道钙吸收减少、体重减轻、皮质醇增加以及飞行后血尿素氮升高，这些变化将它们与模拟飞行研究的动物区分开来。
