Bergan A, Taksdal S, Sander J
Eur Surg Res. 1975;7(6):355-65. doi: 10.1159/000127820.
The role of the lymphatics in the regurgitation of bilirubin during acute and chronic extrahepatic cholestasis in the dog was studied after intravenous injection of 14C-bilirubin. In acute cholestasis the injected labelled bilirubin was rapidly removed from plasma and reappeared in thoracic duct lymph as labelled bilirubin conjugates. No labelled conjugates were at any time demonstrated in plasma. This is most easily explained as a result of a bilio-lymphatic regurgitation. In chronic cholestasis the labelled bilirubin conjugates were delivered back into the blood, and no specific transport function of the lymph was found. Our results indicate a change in liver cell secretory direction in long-standing cholestasis.
在给狗静脉注射14C-胆红素后，研究了淋巴管在急性和慢性肝外胆汁淤积期间胆红素反流中的作用。在急性胆汁淤积中，注入的标记胆红素迅速从血浆中清除，并以标记胆红素结合物的形式重新出现在胸导管淋巴中。血浆中在任何时候都未检测到标记结合物。这最容易解释为胆汁-淋巴反流的结果。在慢性胆汁淤积中，标记的胆红素结合物被重新输送回血液中，未发现淋巴的特定转运功能。我们的结果表明，长期胆汁淤积时肝细胞分泌方向发生了改变。
