Mor L, Bomzon A, Mordechovich D, Blendis L M, Better O S
Biochem Med Metab Biol. 1986 Oct;36(2):252-9. doi: 10.1016/0885-4505(86)90133-7.
Renal handling of bilirubin and its relationship to blood bilirubin level were investigated for up to 2 weeks in two models of jaundiced dogs, namely, chronic bile duct ligation (CBDL), which are mildly icteric, and choledococaval anastomosis (CDCA), which develop deep jaundice. The mean (+/- SD) urinary bilirubin excretion in CBDL plateaued at 30.3 +/- 9.3 mg/24 hr whereas in CDCA it continued to increase above the normal bilirubin production rate (56-84 mg/24 hr) up to 130-150 mg/24 hr. The renal clearance of bilirubin in both models was inversely proportional to serum bilirubin concentration. It was approximately twice as high in the CDCA model, which induced also a moderate diuresis. It is suggested that higher serum bilirubin levels in CDCA dogs is due to the increased production of bilirubin which is not compensated by the renal clearance of bilirubin.
在两种黄疸犬模型中，对胆红素的肾脏处理及其与血胆红素水平的关系进行了长达2周的研究。这两种模型分别是慢性胆管结扎（CBDL），其黄疸程度较轻；以及胆总管腔静脉吻合术（CDCA），其会出现深度黄疸。CBDL模型中尿胆红素排泄的平均值（±标准差）稳定在30.3±9.3mg/24小时，而在CDCA模型中，尿胆红素排泄持续增加，超过正常胆红素生成率（56 - 84mg/24小时），高达130 - 150mg/24小时。两种模型中胆红素的肾脏清除率均与血清胆红素浓度呈反比。在CDCA模型中，胆红素的肾脏清除率大约是前者的两倍，该模型还伴有中度利尿。提示CDCA犬血清胆红素水平较高是由于胆红素生成增加，而肾脏对胆红素的清除未能对其进行代偿。
