Shibahara M, Nanko H, Shimizu M, Kanda N, Kubo M, Ikeda M, Matsumoto M, Nonaka S, Shimizu H
Department of Dermatology, Tokyo Kousei-Nenkin Hospital, Tokyo, Japan.
Dermatology. 2002;204(1):37-42. doi: 10.1159/000051808.
Although dermatitis herpetiformis (DH) is a relatively common disease in Caucasian populations, it is rare in Asian populations including the Japanese. We encountered a Japanese case of DH which showed granular IgA and C3 deposits in the papillary dermis and which was associated with gluten-sensitive enteropathy but no HLA-B8/DR3/DQ2.
The purpose of this study is to describe the characteristics of Japanese DH cases, since most of them have been reported in Japanese language and dermatologists outside Japan are not familiar with the characteristics of Japanese DH.
We have reviewed all 34 Japanese DH cases reported previously.
We found several features of Japanese DH compared with Caucasian DH, such as a high frequency of the fibrillar pattern, rarity of gluten-sensitive enteropathy and an absence of the HLA-B8/DR3/DQ2 haplotype.
There might be significant differences in pathophysiology between Caucasian and Japanese DH cases.
尽管疱疹样皮炎（DH）在白种人群中是一种相对常见的疾病，但在包括日本人在内的亚洲人群中却很罕见。我们遇到了一例日本DH患者，其在乳头真皮层显示颗粒状IgA和C3沉积，且与麸质敏感肠病相关，但无HLA - B8/DR3/DQ2。
本研究的目的是描述日本DH病例的特征，因为大多数此类病例是以日语报道的，日本以外的皮肤科医生并不熟悉日本DH的特征。
我们回顾了先前报道的所有34例日本DH病例。
与白种人DH相比，我们发现了日本DH的几个特征，如纤维状模式的高频率、麸质敏感肠病的罕见性以及HLA - B8/DR3/DQ2单倍型的缺失。
白种人和日本DH病例之间的病理生理学可能存在显著差异。
