D'Andrea F, Brongo S, Ferraro G, Baroni A
Department of Plastic Surgery, Second University of Naples, Italy.
Dermatology. 2002;204(1):60-2. doi: 10.1159/000051812.
The current treatment of keloids is based on surgery, medical therapy and physical treatment. The optimal treatment remains undefined.
This clinical study determines the effectiveness of verapamil hydrochloride on the prevention and treatment of keloids.
Two groups of patients with keloids were divided according to lesion site and age. The first group was treated by perilesional surgical excision of keloids and topical silicone, combined with adjuvant treatment of intralesional 2.5 mg/ml verapamil hydrochloride injections administered at timed intervals. The second group served as control, receiving the same treatment except the verapamil hydrochloride.
A periodical examination to check specific clinical parameters and an 18-month follow-up determined that keloids were cured in 54% of the cases in the first group, compared to 18% in the second group. Moreover, in the remaining 36% of patients in the first group in whom keloids recurred, there was an improvement in size and above all in consistence.
These findings suggest that verapamil hydrochloride is an effective tool for the prevention and therapy of keloids.
瘢痕疙瘩目前的治疗方法包括手术、药物治疗和物理治疗。最佳治疗方法仍不明确。
本临床研究确定盐酸维拉帕米对瘢痕疙瘩预防和治疗的有效性。
根据病变部位和年龄将两组瘢痕疙瘩患者分组。第一组通过瘢痕疙瘩周围手术切除及外用硅酮治疗，并辅助定期病灶内注射2.5mg/ml盐酸维拉帕米。第二组作为对照组，接受除盐酸维拉帕米外的相同治疗。
定期检查特定临床参数并进行18个月随访，结果显示第一组54%的病例瘢痕疙瘩治愈，而第二组为18%。此外，第一组其余36%瘢痕疙瘩复发的患者，其瘢痕疙瘩在大小上，尤其是质地方面有所改善。
这些发现表明盐酸维拉帕米是预防和治疗瘢痕疙瘩的有效手段。
