Jones D T
Department of Biological Sciences, Brunel University, Uxbridge, Middlesex, United Kingdom.
Proteins. 2001;Suppl 5:127-32. doi: 10.1002/prot.1171.
The results of applying a fragment-based protein tertiary structure prediction method to the prediction of 8 CASP4 targets are described. The method is based on the assembly of supersecondary structural fragments taken from highly resolved protein structures using a simulated annealing algorithm. Despite the significant degree of success in this case, there is clearly much more developmental work required before predictions with the accuracy of a good homology model, or even a good fold recognition model, can be made with use of this kind of approach.
描述了将基于片段的蛋白质三级结构预测方法应用于8个CASP4靶标的预测结果。该方法基于使用模拟退火算法从高度解析的蛋白质结构中提取的超二级结构片段进行组装。尽管在这种情况下取得了显著的成功，但在利用这种方法做出具有良好同源性模型甚至良好折叠识别模型精度的预测之前，显然还需要进行更多的开发工作。
