Karkishchenko N N, Khaĭtin M I
Farmakol Toksikol. 1982 Mar-Apr;45(2):126-30.
A comprehensive analysis of the cat brain electrograms (EG) by computer has revealed that the derivatives of 1,4-benzodiazepine (chlorodiazepoxide, diazepam) selectivity increase the modules of brain transients within the ranges of 8-12 and 10-12 Hz largely on the EG of the proreal gyrus and paleocortical structures and raise in the same spectral region the level of coherence between biopotentials of the limbic structures, displace the coefficients of asymmetry and excess unidimensional distributions of the instantaneous values of the EG amplitudes towards negative magnitudes. The indicators in question may be used as differential criteria of the tranquilizing effect of neurotropic substances. It is suggested that the increase in the modules of brain transients within the ranges of 8-10, 10-12 Hz during exposure to neurotropic substances is likely to mirror their central GABA-ergic mechanisms and to be an integral electrophysiological correlate of tranquilization as a psychophysiological state.
通过计算机对猫脑电描记图（EG）进行的综合分析表明，1,4 - 苯二氮䓬类药物（氯氮卓、地西泮）的衍生物可选择性增加8 - 12赫兹和10 - 12赫兹范围内脑瞬变信号的模量，主要体现在颞叶前回和古皮质结构的EG上，并在同一频谱区域提高边缘结构生物电位之间的相干水平，使EG振幅瞬时值的不对称系数和单维分布的过量向负值方向移动。上述指标可用作神经营养物质镇静作用的鉴别标准。有人提出，在接触神经营养物质期间，8 - 10赫兹、10 - 12赫兹范围内脑瞬变信号模量的增加可能反映了它们的中枢γ-氨基丁酸能机制，并且是作为一种心理生理状态的镇静作用的整体电生理相关指标。
