Zellos Lambros S, Sugarbaker David J
Department of Surgery, Division of Thoracic Surgery, Brigham and Women's Hospital, Boston, MA 02115, USA.
Semin Oncol. 2002 Feb;29(1):41-50. doi: 10.1053/sonc.2002.30230.
Diffuse malignant pleural mesothelioma (DMPM) is a challenging disease in all of its aspects, from presentation and diagnosis to staging and treatment. Single-modality therapy was the initial approach to this disease. It generally has not been effective in changing the natural history of DMPM. As a result, multimodality regimens involving surgery with radiation, chemotherapy, or immunotherapy delivered regionally or systemically have been evaluated. Randomized controlled studies comparing various strategies are lacking and, thus, the debate continues regarding the effectiveness of different treatment approaches.
弥漫性恶性胸膜间皮瘤（DMPM）在其各个方面都是一种具有挑战性的疾病，从临床表现、诊断到分期和治疗。单模态疗法是针对这种疾病的最初治疗方法。它通常在改变DMPM的自然病程方面效果不佳。因此，已经对涉及手术联合放疗、化疗或区域或全身免疫治疗的多模态治疗方案进行了评估。缺乏比较各种策略的随机对照研究，因此，关于不同治疗方法的有效性的争论仍在继续。
