Beuf Olivier, Ghosh Srinka, Newitt David C, Link Thomas M, Steinbach Lynne, Ries Michael, Lane Nancy, Majumdar Sharmila
University of California San Francisco, 1 Irving Street, San Francisco, CA 94143-1290, USA.
Arthritis Rheum. 2002 Feb;46(2):385-93. doi: 10.1002/art.10108.
To use high-resolution magnetic resonance imaging (MRI) to evaluate the trabecular bone structure in the distal femur and the proximal tibia and its to correlate the findings with different stages of osteoarthritis (OA) of the human knee.
Axial images of the distal femur and proximal tibia were obtained at 1.5 T in patients without and with mild OA and with severe OA. The spatial resolution was 195 x 195 microm(2) with a 1-mm slice thickness. Apparent measures of trabecular bone volume fraction (BV/TV), trabecular number (Tb.N), trabecular separation (Tb.Sp), and trabecular thickness (Tb.Th) were calculated.
Significant differences existed in the trabecular bone structure of the femur and tibia. Differences in trabecular bone structure between the tibia and the femur decreased with the degree of OA. The apparent BV/TV, Tb.N, and Tb.Sp in the femoral condyles could be used to differentiate healthy patients or patients with mild OA from patients with severe OA (P < 0.05). Among individuals, the structural variation of the lateral and medial femoral condyle was indicative of the extent of the disease.
High-resolution MRI of the knee joint can provide a noninvasive assessment of trabecular bone structure. Trabecular bone structure, determined by high-resolution MRI, shows significant variation in patients with varying degrees of OA. The impact of OA on trabecular bone is different in the tibia than in the femur, and this difference depends on the extent of the disease.
运用高分辨率磁共振成像（MRI）评估股骨远端和胫骨近端的小梁骨结构，并将结果与人类膝关节骨关节炎（OA）的不同阶段相关联。
在1.5T条件下获取无OA、轻度OA和重度OA患者的股骨远端和胫骨近端的轴向图像。空间分辨率为195×195微米²，层厚1毫米。计算小梁骨体积分数（BV/TV）、小梁数量（Tb.N）、小梁间距（Tb.Sp）和小梁厚度（Tb.Th）的表观测量值。
股骨和胫骨的小梁骨结构存在显著差异。胫骨和股骨之间小梁骨结构的差异随OA程度降低。股骨髁的表观BV/TV、Tb.N和Tb.Sp可用于区分健康患者或轻度OA患者与重度OA患者（P<0.05）。在个体中，股骨内外侧髁的结构变化表明疾病的程度。
膝关节高分辨率MRI可提供小梁骨结构的无创评估。高分辨率MRI确定的小梁骨结构在不同程度OA患者中显示出显著差异。OA对小梁骨的影响在胫骨和股骨中不同，且这种差异取决于疾病的程度。
