Lindsey C T, Narasimhan A, Adolfo J M, Jin Hua, Steinbach L S, Link T, Ries M, Majumdar S
Magnetic Resonance Science Center, University of California, CA, San Francisco, USA.
Osteoarthritis Cartilage. 2004 Feb;12(2):86-96. doi: 10.1016/j.joca.2003.10.009.
To use high-resolution magnetic resonance imaging (MRI) to determine the relationship between articular cartilage degeneration and trabecular bone changes of the femur, condyles and tibia in human knees with osteoarthritis (OA).
Subjects were divided into three groups: without OA (OA0), mild OA (OA1) and severe OA (OA2). Sagittal images of the knee (0.234 x 0.234mm2, 2-mm slice thickness) were obtained at 1.5T and used for calculating the volume and thickness of the femoral and tibial cartilage. Axial images (0.195 x 0.195mm2, 1-mm slice thickness) were used for calculating the trabecular bone structure parameters: apparent bone volume fraction, trabecular number, trabecular separation and trabecular thickness.
Cartilage volume and thickness were less in patients with OA compared to normal controls (P<0.1). Articular cartilage thinning is associated with bone structure loss in the opposite femoral condyle (P<0.05). In varus OA, there were extensive correlations between medial tibia and medial femoral cartilage degeneration, and loss of bone structure in the lateral tibia and lateral condyle. Additional correlations existed between the compartmental differences (lateral minus medial) of cartilage thickness and bone structure.
Degradation of articular cartilage within a compartment correlates with a loss of bone structure in the opposite compartment. The correlation between the (L-M) differences corroborates this relationship. Malalignment of the knee due to cartilage degeneration is associated with bone formation in the diseased condyle and bone resorption in the opposite compartment.
运用高分辨率磁共振成像（MRI）确定骨关节炎（OA）患者膝关节中股骨、髁和胫骨的关节软骨退变与小梁骨变化之间的关系。
将受试者分为三组：无OA（OA0）、轻度OA（OA1）和重度OA（OA2）。在1.5T条件下获取膝关节矢状位图像（0.234×0.234mm2，层厚2mm），用于计算股骨和胫骨软骨的体积和厚度。轴向图像（0.195×0.195mm2，层厚1mm）用于计算小梁骨结构参数：表观骨体积分数、小梁数量、小梁间距和小梁厚度。
与正常对照组相比，OA患者的软骨体积和厚度较小（P<0.1）。关节软骨变薄与对侧股骨髁的骨结构丧失相关（P<0.05）。在膝内翻OA中，内侧胫骨和内侧股骨软骨退变与外侧胫骨和外侧髁的骨结构丧失之间存在广泛相关性。软骨厚度和骨结构的分区差异（外侧减去内侧）之间还存在其他相关性。
一个分区内的关节软骨退变与对侧分区的骨结构丧失相关。（L-M）差异之间的相关性证实了这种关系。由于软骨退变导致的膝关节排列不齐与患病髁的骨形成和对侧分区的骨吸收有关。
