Maemura Yumi
First Department of Anesthesiology, Toho University School of Medicine, Tokyo 143-8541.
Masui. 2002 Jan;51(1):19-24.
It is well know that the amide-linked local anesthetics such as lidocaine accelerate Ca induced Ca release (CICR) rate. Since ropivacaine is a new amide-linked local anesthetic, effects of ropivacaine on Ca functions were studied using skinned skeletal muscle. The extensor digitorum longus muscle of male Hartley guinea pigs of about 500 g was prepared for this study. According to Endo's method, CICR rates were measured using chemically skinned fibers. Ropivacaine accelerated the (CICR) rate only at concentrations of 3 mM and 10 mM with pCa 5.0. Ropivacaine at a concentration of 10 mM inhibited initial rate of Ca uptake by sarcoplasmic reticulum. Ca sensitivity of the contractile system was not affected with 10 mM of ropivacaine. These results suggest that ropivacaine can be used safely in patients susceptible to malignant hyperthermia since ropivacaine 3 mM is not a concentration for clinical use.
众所周知，酰胺类局部麻醉药如利多卡因可加速钙诱导的钙释放（CICR）速率。由于罗哌卡因是一种新型酰胺类局部麻醉药，因此使用去表皮骨骼肌研究了罗哌卡因对钙功能的影响。本研究选用体重约500 g的雄性哈特利豚鼠的趾长伸肌。根据远藤的方法，使用化学去表皮纤维测量CICR速率。仅在3 mM和10 mM浓度、pCa 5.0条件下，罗哌卡因可加速CICR速率。浓度为10 mM的罗哌卡因可抑制肌浆网对钙的初始摄取速率。10 mM的罗哌卡因不影响收缩系统的钙敏感性。这些结果表明，3 mM罗哌卡因并非临床使用浓度，因此罗哌卡因可安全用于易患恶性高热的患者。
