Ichihara Y
First Department of Anesthesiology, Toho University School of Medicine, Tokyo.
Masui. 1998 Mar;47(3):281-5.
The aim of this study is to assess the effect of temperature on CICR rate. The extensor digitorum longus muscles of male Hartley guinea pigs of about 450 g, were prepared for this study. According to Endo's method, CICR rates were measured using chemically skinned fibers. Two plates were prepared: one at 20 degrees C and the other at 30, 35, 37, 40 degrees C controlled by circulating water at an appropriate temperature placed underneath each plate. The whole procedure was carried out at 20 degrees C except the step of CICR using a plate at a given temperature. An increase in temperature (20 to 40 degrees C) accelerated CICR rate in a logarithmic manner. These experimental findings suggest that cooling of the patient's body is important not only to control metabolism but also to reduce an accelerated CICR rate.
本研究的目的是评估温度对钙诱导钙释放（CICR）速率的影响。本研究选用体重约450克的雄性哈特利豚鼠的趾长伸肌。根据远藤的方法，使用化学去膜纤维测量CICR速率。制备两块板：一块置于20℃，另一块置于30、35、37、40℃，通过置于每块板下方的循环水在适当温度下进行控制。除了在给定温度下使用一块板进行CICR的步骤外，整个过程均在20℃下进行。温度升高（20至40℃）以对数方式加速CICR速率。这些实验结果表明，降低患者体温不仅对控制新陈代谢很重要，而且对降低加速的CICR速率也很重要。
