和的二萜类化合物及其抗炎活性。
Diterpenoids from and Their Anti-Inflammatory Activities.
机构信息
School of Pharmacy, Lanzhou University, Lanzhou 730000, China.
Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen 518060, China.
出版信息
Molecules. 2022 Apr 30;27(9):2890. doi: 10.3390/molecules27092890.
Six new diterpenoids, blusamiferoids A-F (-), including four pimarane-type diterpenoids, one rosane-type diterpenoid (), and one rearranged abietane-type diterpenoid (), were isolated from the dry aerial parts of Their structures were characterized by spectroscopic and computational methods. In particular, the structures of and were confirmed by X-ray crystallography. Compounds and were found to dose-dependently inhibit the production of TNF-α, IL-6, and nitrite oxide, and compound also downregulated NF-B phosphorylation in lipopolysaccharide (LPS)-induced RAW 264.7 cells.
从干燥的空中部分中分离得到了六种新的二萜类化合物，包括四种贝壳杉烷型二萜类化合物、一种松香烷型二萜类化合物 () 和一种重排的枞烷型二萜类化合物 ()。通过光谱和计算方法确定了它们的结构。特别是，化合物和的结构通过 X 射线晶体学得到了证实。发现化合物和能够剂量依赖性地抑制 TNF-α、IL-6 和亚硝酸盐氧化物的产生，并且化合物也下调了脂多糖 (LPS) 诱导的 RAW 264.7 细胞中 NF-B 的磷酸化。
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