Weichselbaum R R, Zakov Z N, Albert D M, Friedman A H, Nove J, Little J B
Ophthalmology. 1979 Jun;86(6):1191-201. doi: 10.1016/s0161-6420(79)35429-x.
New clinical and pathologic findings in patients with deletion of the long arm of chromosome 13 (13q-) include optic nerve hypoplasia and retinal dysplasia. Fibroblasts derived from patients with a 13q- syndrome with and without retinoblastoma, as well as from familial and sporadic retinoblastoma, are a useful model for the study of genetic susceptibility to the development of spontaneous and radiation-induced cancers. Fibroblasts from patients with hereditary retinoblastoma appear more radiosensitive than fibroblasts from patients with sporadic retinoblastoma or normal control patients.
