Ahlberg M, Bergström J, Fürst P, Josephson B, Norée L O, Vinnars E
Infusionsther Klin Ernahr. 1975 Jun;2(3):151-7. doi: 10.1159/000219607.
Nitrogen balance studies in chronic severe uremia have shown that it is possible to convert the negative nitrogen balance on a protein-poor diet to a positive one when the diet is supplemented with the essential amino acids intravenously or orally. It has been possible to make the diet variable and good tasting. This is a great advance as the patients can remain on the diet for a long time. 15N-studies have shown that this nitrogen balance represents true protein synthesis. These studies have also shown that histidine may be an essential amino acid in chronic severe uremia and further improves the nitrogen balance. During long-term treatment with the diet supplemented with essential amino acids including histidine, no signs of progressive neuropathy, bleeding or muscle wasting have been observed. We think that this diet and amino acid regimen is a feasible way to keep chronic severe uremic patients in fairly good general condition and nutritive state until they can have a renal transplantation or a place in a home-dialysis program.
慢性重度尿毒症的氮平衡研究表明，在低蛋白饮食基础上，通过静脉或口服补充必需氨基酸，有可能将负氮平衡转变为正氮平衡。现已能够使饮食多样化且味道良好。这是一项重大进展，因为患者能够长期坚持这种饮食。氮-15研究表明，这种氮平衡代表真正的蛋白质合成。这些研究还表明，组氨酸在慢性重度尿毒症中可能是一种必需氨基酸，可进一步改善氮平衡。在用补充了包括组氨酸在内的必需氨基酸的饮食进行长期治疗期间，未观察到进行性神经病变、出血或肌肉萎缩的迹象。我们认为，这种饮食和氨基酸方案是使慢性重度尿毒症患者保持相当良好的一般状况和营养状态的可行方法，直至他们能够接受肾移植或在家中进行透析治疗。
