Watson H G, Chee Y L, Greaves M
Department of Medicine and Therapeutics, University of Aberdeen, Polworth Building, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK.
Rev Clin Exp Hematol. 2001 Dec;5(4):405-29; quiz following 431. doi: 10.1046/j.1468-0734.2001.00050.x.
Accurate diagnosis of the cause of bleeding is a prerequisite for determination of the optimal therapeutic response. Clinicians are generally aware of the more prevalent hemorrhagic syndromes but some rare acquired conditions are also of importance. In many of these, inhibitors of coagulation factors or of platelet adhesion/aggregation cause bleeding. These inhibitors are generally, but not always, immunoglobulins. In this review, the less common inhibitors of coagulation and hemostasis, as well as some important but rare nutritional, iatrogenic and disease associated hemorrhagic disorders, are described.
准确诊断出血原因是确定最佳治疗反应的前提。临床医生通常了解较为常见的出血综合征，但一些罕见的后天性疾病也很重要。在许多此类疾病中，凝血因子或血小板黏附/聚集的抑制剂会导致出血。这些抑制剂通常（但并非总是）是免疫球蛋白。在本综述中，将描述不太常见的凝血和止血抑制剂，以及一些重要但罕见的营养性、医源性和疾病相关的出血性疾病。
