Arain Abeer, Muhsen Ibrahim N, Abdelrahim Maen
Houston Methodist Cancer Center, Houston Methodist Hospital, Houston, TX 77030, USA.
https://orcid.org/0000-0001-6295-4318.
Ecancermedicalscience. 2020 Jun 4;14:1053. doi: 10.3332/ecancer.2020.1053. eCollection 2020.
Acquired haemophilia is a severe haematological disorder characterised by the presence of anti-factor VIII antibodies. Although rare, it can lead to serious bleeding complications. Acquired haemophilia can be seen in patients with malignancies as a paraneoplastic phenomenon. This is a case of a 52-year-old patient who presented with haematuria and retroperitoneal bleeding soon after being diagnosed with pancreatic adenocarcinoma and subsequently was found to have acquired haemophilia. The treatment of underlying malignancy with chemotherapy may accelerate the eradication of anti-factor VIII antibodies.
获得性血友病是一种严重的血液系统疾病，其特征是存在抗凝血因子 VIII 抗体。尽管罕见，但它可导致严重的出血并发症。获得性血友病可在恶性肿瘤患者中作为副肿瘤现象出现。这是一例 52 岁的患者，在被诊断为胰腺腺癌后不久出现血尿和腹膜后出血，随后被发现患有获得性血友病。用化疗治疗潜在的恶性肿瘤可能会加速抗凝血因子 VIII 抗体的消除。
