合成石蒜科菌素 A 的卡洛林二糖结构域。
Synthesis of the carboline disaccharide domain of shishijimicin A.
机构信息
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
出版信息
Org Lett. 2011 Aug 5;13(15):3924-7. doi: 10.1021/ol201444t. Epub 2011 Jun 28.
Abstract
A synthetic route to the carboline disaccharide domain (2) of shishijimicin A (1) has been developed. The convergent synthesis relies on a novel application of the Reetz-Müller-Starke reaction to form the central, sulfur-bearing quaternary carbon center and addition of the carboline structural motif as a dianion to a disaccharide aldehyde fragment.
摘要
已经开发出一种合成石蒜科霉素 A（1）的卡洛林二糖结构域（2）的方法。这种收敛合成依赖于 Reetz-Müller-Starke 反应的新应用，以形成中央含硫的季碳中心，并将卡洛林结构基序作为二阴离子添加到二糖醛片段中。
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