Scudder Charles A, Kaneko Chris S, Fuchs Albert F
Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Exp Brain Res. 2002 Feb;142(4):439-62. doi: 10.1007/s00221-001-0912-9. Epub 2002 Jan 9.
In the 16 years since we last summarized the behavior of the premotor elements that control saccades, research has revealed shortcomings in previous formulations of the control mechanisms of the brainstem saccadic burst generator. Specifically, complexities in the eye movement plant, a more detailed knowledge of the behaviors of certain bursting neurons, and previously undiscovered anatomical connections have broadened our knowledge but have generated new questions that require rethinking previous concepts. Perhaps the most crucial revelations/insights have come from studies that have implicated the superior colliculus and the midline cerebellum as crucial elements of the burst generator. In summarizing these recent findings here, we have been led to conclude that the superior colliculus issues the saccadic command and receives feedback from the brainstem burst generators, but the feedback does not control saccade size. In addition, the midline cerebellum also contains a feedback path, but only as part of a more generalized circuit that serves multiple functions.
自从我们上次总结控制扫视的运动前区元件的行为以来的16年里，研究揭示了脑干扫视爆发发生器控制机制先前表述中的不足之处。具体而言，眼球运动装置的复杂性、对某些爆发性神经元行为的更详细了解以及先前未被发现的解剖学连接拓宽了我们的知识，但也产生了需要重新思考先前概念的新问题。也许最关键的发现来自于那些将上丘和中线小脑视为爆发发生器关键元件的研究。在这里总结这些最新发现时，我们得出结论：上丘发出扫视指令并接收来自脑干爆发发生器的反馈，但该反馈并不控制扫视幅度。此外，中线小脑也包含一条反馈路径，但它只是作为一个具有多种功能的更广义回路的一部分。
