Klungland H, Sabry A, Heringstad B, Olsen H G, Gomez-Raya L, Våge D I, Olsaker I, Ødegård J, Klemetsdal G, Schulman N, Vilkki J, Ruane J, Aasland M, Rønningen K, Lien S
Department of Animal Science, Agricultural University of Norway, P.O. Box 5025, N-1432 As, Norway.
Mamm Genome. 2001 Nov;12(11):837-42. doi: 10.1007/s00335001-2081-3.
Norway has a field recording system for dairy cattle that includes recording of all veterinary treatments on an individual animal basis from 1978 onwards. Application of these data in a genome search for quantitative trait loci (QTL) verified genome-wise significant QTL affecting clinical mastitis on Chromosome (Chr) 6. Additional putative QTL for clinical mastitis were localized to Chrs. 3, 4, 14, and 27. The comprehensive field recording system includes information on somatic cell count as well. This trait is often used in selection against mastitis when direct information on clinical mastitis is not available. The absence of common QTL positions for the two traits in our study indicates that the use of somatic cell count data in QTL studies aimed for reducing the incidence of mastitis should be carefully evaluated.
挪威有一个奶牛实地记录系统，该系统自1978年起记录每头奶牛的所有兽医治疗情况。在一项寻找数量性状基因座（QTL）的基因组研究中应用这些数据，验证了影响6号染色体（Chr）临床乳腺炎的全基因组显著QTL。临床乳腺炎的其他假定QTL定位于Chr 3、4、14和27。这个全面的实地记录系统还包括体细胞计数信息。当没有临床乳腺炎的直接信息时，这个性状常用于抗乳腺炎的选择。我们研究中这两个性状缺乏共同的QTL位置，这表明在旨在降低乳腺炎发病率的QTL研究中，体细胞计数数据的使用应谨慎评估。
