Saltiel Alan R, Pessin Jeffrey E
Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109-0650, USA.
Trends Cell Biol. 2002 Feb;12(2):65-71. doi: 10.1016/s0962-8924(01)02207-3.
Despite remarkable progress in dissecting the signaling pathways that are crucial for the metabolic effects of insulin, the molecular basis for the specificity of its cellular actions is not fully understood. One clue might lie in the spatial and temporal aspects of signaling. Recent evidence suggests that signaling molecules and pathways are localized to discrete compartments in cells by specific protein interactions. Also, the rapid termination of tyrosine or lipid phosphorylation by phosphatases or serine kinases might tightly control the strength of a signaling pathway, thus determining its effect on growth, differentiation and metabolism.
尽管在剖析对胰岛素代谢作用至关重要的信号通路方面取得了显著进展，但其细胞作用特异性的分子基础仍未完全明确。一条线索可能存在于信号传导的时空方面。最近的证据表明，信号分子和信号通路通过特定的蛋白质相互作用定位于细胞内离散的区室中。此外，磷酸酶或丝氨酸激酶对酪氨酸或脂质磷酸化的快速终止可能会严格控制信号通路的强度，从而决定其对生长、分化和代谢的影响。
