Nedosugova Lyudmila V, Markina Yuliya V, Bochkareva Leyla A, Kuzina Irina A, Petunina Nina A, Yudina Irina Y, Kirichenko Tatiana V
Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia.
Petrovsky National Research Center of Surgery, 119991 Moscow, Russia.
Biomedicines. 2022 May 18;10(5):1168. doi: 10.3390/biomedicines10051168.
The main cause of death in patients with type 2 DM is cardiovascular complications resulting from the progression of atherosclerosis. The pathophysiology of the association between diabetes and its vascular complications is complex and multifactorial and closely related to the toxic effects of hyperglycemia that causes increased generation of reactive oxygen species and promotes the secretion of pro-inflammatory cytokines. Subsequent oxidative stress and inflammation are major factors of the progression of type 2 DM and its vascular complications. Data on the pathogenesis of the development of type 2 DM and associated cardiovascular diseases, in particular atherosclerosis, open up broad prospects for the further development of new diagnostic and therapeutic approaches.
2型糖尿病患者的主要死因是动脉粥样硬化进展导致的心血管并发症。糖尿病与其血管并发症之间关联的病理生理学复杂且具有多因素性，并且与高血糖的毒性作用密切相关，高血糖会导致活性氧生成增加并促进促炎细胞因子的分泌。随后的氧化应激和炎症是2型糖尿病及其血管并发症进展的主要因素。关于2型糖尿病及相关心血管疾病（尤其是动脉粥样硬化）发病机制的数据，为新诊断和治疗方法的进一步发展开辟了广阔前景。
