Kilham L, Margolis G
J Infect Dis. 1975 Oct;132(4):462-6. doi: 10.1093/infdis/132.4.462.
The abilities of a low-passage strain and of a live, attenuated vaccine strain of mumps virus to induce congenital hydrocephalus in hamsters were tested by intraamniotic inoculation on the 10th day of pregnancy. Examination of term fetuses and neonates, with cytoplasmic inclusions, cytopathic effects, and specific immunofluorescence used as indicators, demonstrated an oronasal portal of entry for both strains. The vaccine strain appeared to be more pathogenic; it spread primarily into the respiratory tract and hence to the central nervous system. Inclusions were observed as long as 21 days after inoculation. Hydrocephalus and ependymal involvement, potentially capable of producing aqueductal stenosis, were observed in 19 of 81 animals studied 11-29 days after inoculation.
在妊娠第10天通过羊膜腔内接种，测试了腮腺炎病毒低传代毒株和减毒活疫苗毒株在仓鼠中诱发先天性脑积水的能力。以细胞质内包涵体、细胞病变效应和特异性免疫荧光为指标，对足月胎儿和新生儿进行检查，结果表明两种毒株均经口鼻途径进入。疫苗毒株似乎致病性更强；它主要扩散到呼吸道，进而扩散到中枢神经系统。接种后长达21天均可观察到包涵体。在接种后11 - 29天研究的81只动物中，有19只出现了脑积水和室管膜受累，这可能会导致导水管狭窄。
