Wolinsky J S
Lab Invest. 1977 Sep;37(3):229-36.
Newborn hamsters were inoculated intraperitoneally with neuroadapted mumps virus and sacrificed at intervals from days 3 through 50. Intracytoplasmic collections of nucleocapsids were found in ependymal cells and neurons on days 3 and 5 and virus formed at the plasma membrane of such cells by building. At closely apposed ventricular surfaces, mature particles appeared to form "bridges" between cilia of adjacent cells. Intracytoplasmic collections of nucelocapsids without evidence of maturation from cell surfaces could be found in ependyma for as long as 33 days. At the sites of apparent aqueductal occlusion, located in several animals, were found enlarged and distorted ependymal cells that did not define a lumen. The ependyma lining hydrocephalic lateral ventricles showed markedly attenuated cytoplasmic processes. Ependymal lined channels frequently coursed below the ventricular surface. Interstitial edema separated parenchymal elements of the underlying white matter. Conversion from an acute productive phase of infection to a chronic, nonproductive phase of infection in this model has ultrastructural correlates that appear to typify persistent paramyxoviral infections of brain.
新生仓鼠经腹腔接种神经适应型腮腺炎病毒，并在第3天至第50天期间每隔一段时间处死一批。在第3天和第5天，在室管膜细胞和神经元中发现核衣壳的胞质内聚集物，病毒通过组装在这些细胞的质膜上形成。在紧密相邻的脑室表面，成熟颗粒似乎在相邻细胞的纤毛之间形成“桥”。在室管膜中，可发现长达33天的无细胞表面成熟迹象的核衣壳胞质内聚集物。在几只动物中，在明显的导水管阻塞部位发现室管膜细胞肿大和变形，管腔不明显。脑积水侧脑室的室管膜显示其细胞质突起明显变细。室管膜衬里的通道经常在脑室表面下方走行。间质性水肿分隔了下方白质的实质成分。在该模型中，从感染的急性增殖期转变为慢性非增殖期具有超微结构相关性，这似乎是脑内副粘病毒持续感染的典型特征。
