用腮腺炎病毒在恒河猴中诱导先天性脑积水。
Induction of congenital hydrocephalus with mumps virus in rhesus monkeys.
作者信息
London W T, Kent S G, Palmer A E, Fucillo D A, Houff S A, Saini N, Sever J L
出版信息
J Infect Dis. 1979 Mar;139(3):324-8. doi: 10.1093/infdis/139.3.324.
Rhesus monkey fetuses were inoculated intracerebrally with wild-type mumps virus near the beginning of the last third of the gestation period. Within three days after inoculation, mumps virus was isolated from many fetal tissues. Thirteen animals receiving virus were delivered at term. Five of these showed slight to severe hydrocephalus. Hydrocephalus was most prominent in the posterior horns of the lateral ventricles, but other lesions occurred at various levels of the ventricular system. Virus was isolated from three animals at one day of age (two months after inoculation). However, mumps virus was not recovered from one-month-old monkeys. The recovery of mumps virus from newborn rhesus monkeys two months after inoculation suggests that attempts should be made to document similar persistence of the virus in humans. Furthermore, this model indicates that mumps virus infection in humans may result in hydrocephalus.
在妊娠晚期接近三分之一时，将野生型腮腺炎病毒脑内接种到恒河猴胎儿体内。接种后三天内，从许多胎儿组织中分离出腮腺炎病毒。13只接种病毒的动物足月分娩。其中5只出现了轻度至重度脑积水。脑积水在侧脑室后角最为明显，但在脑室系统的不同水平也出现了其他病变。在出生一天（接种后两个月）时，从三只动物体内分离出病毒。然而，在1月龄的猴子中未分离出腮腺炎病毒。接种两个月后从新生恒河猴体内分离出腮腺炎病毒，这表明应该尝试证明该病毒在人类中也有类似的持续性感染情况。此外，该模型表明人类感染腮腺炎病毒可能导致脑积水。
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