Schlesinger K, Harkins J, Deckard B S, Paden C
J Neurobiol. 1975 Nov;6(6):587-96. doi: 10.1002/neu.480060605.
The activities of catechol-O-methyl transferase (COMT), monoamine oxidase (MAO), and a methanol forming enzyme were studied in whole brain homogenates and in livers obtained from DBA/2J, C57B1/6J, and F1 hybrid mice. DBA/2J mice are extremely susceptible to audiogenic seizures, whereas C57B1/6J mice are resistant to sound-induced convulsions. C57B1/6J mice were found to have significantly higher brain levels of COMT, while MAO activities were not different in animals of these genotypes. No methanol forming activity was detected in animals of either strain. No differences were found in hepatic activities of either COMT or MAO. Pyrogallol was shown to protect DBA/2J animals against audiogenic seizures.
对从DBA/2J、C57B1/6J和F1杂交小鼠获得的全脑匀浆和肝脏中的儿茶酚-O-甲基转移酶（COMT）、单胺氧化酶（MAO）以及一种甲醇形成酶的活性进行了研究。DBA/2J小鼠极易发生听源性癫痫发作，而C57B1/6J小鼠对声音诱发的惊厥具有抗性。发现C57B1/6J小鼠大脑中的COMT水平显著更高，而这些基因型动物的MAO活性并无差异。在这两种品系的动物中均未检测到甲醇形成活性。COMT或MAO的肝脏活性未发现差异。已表明连苯三酚可保护DBA/2J动物免受听源性癫痫发作。
