Doyle R L, Sellinger O Z
Pharmacol Biochem Behav. 1980 Oct;13(4):589-91. doi: 10.1016/0091-3057(80)90286-5.
The specific acitivity of cerebral histamine N-methyltransferase (HMT) was significantly lower in the audiogenic seizure-susceptible (SS) 21-day old DBA/2J mouse when compared to the non-susceptible 70-day old DBA/2J mouse but not when compared to the seizure resistant (SR) C57B1/6J mouse at 21 days of age. There was no significant difference between the two strains at 70 days of age. The lower HMT specific activity was also observed in a SS mutant of the deermouse Peromyuscus maniculatus, relative to the SR, wild-type animal. The activity of cerebral catechol-O-methyltransferase (COMT) was significantly lower in the DBA/2J mice relative to the C57B1/6J at 21 and 70 days while, in Peromyscus, it was higher in the SS mutant than in the SR animal. The activity of MAO, B was lower in the 21-day old, relative to the 70-day old DBA/2J and the 21-day old C57B1/6J mice. There were no differences in MAO A or B between SS and SR Peromyscus. The findings raise the possibility that cerebral methylation may operate at characteristic rates in SS animals.
与不易感的70日龄DBA/2J小鼠相比，21日龄对声源性癫痫敏感（SS）的DBA/2J小鼠脑内组胺N-甲基转移酶（HMT）的比活性显著降低，但与21日龄抗癫痫（SR）的C57B1/6J小鼠相比则无显著差异。70日龄时，这两个品系之间没有显著差异。相对于SR野生型动物，在鹿鼠（白足鼠）的一个SS突变体中也观察到较低的HMT比活性。在21日龄和70日龄时，DBA/2J小鼠脑内儿茶酚-O-甲基转移酶（COMT）的活性相对于C57B1/6J小鼠显著降低，而在白足鼠中，SS突变体中的COMT活性高于SR动物。相对于70日龄的DBA/2J小鼠和21日龄的C57B1/6J小鼠，21日龄小鼠的MAO B活性较低。SS和SR白足鼠之间的MAO A或B没有差异。这些发现增加了大脑甲基化可能在SS动物中以特定速率发挥作用的可能性。
