Lecompte F, Castaing M, Joubin C, Pocidalo J J
Biomedicine. 1976 Dec 5;25(9):331-4.
The influence of oxygenation in respiratory and metabolic acid-base disturbances on erythocyte pH has been studied on normal human blood "in vitro". In physiological pH range, pHe-pHi relationship is the same for PCO2 variations at constant metabolic level and for metablic level variations at constant PCO2. A "global" pHe-pHi relationship has been calculated at 0 and 100% SO2. The oxygen-linked pH shift depends on pH level and PCO2 and is different in plasma and erythrocyte. From these results arise conclusions on pHi and pHe dependency, physiological role of saturation level of hemoglobin and conditions of P50 normalisation at pH 7.4.
在体外对正常人血液研究了呼吸性和代谢性酸碱紊乱中氧合作用对红细胞pH值的影响。在生理pH范围内，对于恒定代谢水平下的PCO2变化以及恒定PCO2下的代谢水平变化，pHe-pHi关系是相同的。已计算出在0和100% SO2时的“总体”pHe-pHi关系。氧相关的pH偏移取决于pH水平和PCO2，且在血浆和红细胞中有所不同。从这些结果得出了关于pHi和pHe依赖性、血红蛋白饱和度水平的生理作用以及pH 7.4时P50正常化条件的结论。
