Gordillo-Paniagua G, Velásquez-Jones L, Martini R, Valdez-Bolaños E
J Pediatr. 1975 Nov;87(5):799-802. doi: 10.1016/s0022-3476(75)80314-3.
Severe arterial hypertension in children constitutes a high-risk situation requiring rapid and effective therapy. We have assessed the clinical value of sodium nitroprusside as a rapidly acting antihypertensive agent. Twenty children admitted with hypertensive crises of renal origin were treated with intravenous infusion of sodium nitroprusside at an average rate of 1.4 mug/kg/min. Desired levels of blood pressure were reached in all patients within one to 20 minutes. Rapid improvement of cardiac failure was observed in all patients, and neurologic signs of distress disappeared in 16 of the 20 children within 24 to 48 hours of treatment, permitting substitution of oral medication. One patient died of cerebral hemorrhage without improvement of encephalopathy. There were no undesirable effects of therapy or deterioration of renal function in any patient.
儿童重度动脉高血压是一种高危情况，需要迅速有效的治疗。我们评估了硝普钠作为一种速效抗高血压药物的临床价值。20例因肾源性高血压危象入院的儿童接受了硝普钠静脉输注治疗，平均输注速度为1.4微克/千克/分钟。所有患者在1至20分钟内达到了理想的血压水平。所有患者的心衰均迅速改善，20名儿童中有16名在治疗24至48小时内神经窘迫症状消失，从而可以改用口服药物。1例患者死于脑出血，脑病无改善。所有患者均未出现治疗不良反应或肾功能恶化。
