Stefanov G, Vretenarska M, Tishkov I, Dimov B
Vutr Boles. 1982;21(5):58-62.
After a brief literature survey, the authors share their experience of the treatment of hypertonic crises and acute left cardiac insufficiency of renal patients via Naniprus, a preparation produced in P.R. of Bulgaria. The patients' age was from 11 to 64. With an average basal arterial pressure (AP) 25.2/14.5 kPa during the crises the patients had an average AP of 33.3/20.0 kPa and only three minutes after the initiation of its drop infusion it was reduced to an average of 25. 1/14.7 kPa (p less than 0.001). In one child with severe pulmonary edema in the progress of a hypertonic crisis, in a crisis for rejection of transplanted kidney, they infused Naniprus continuously for 5 days and nights, and in another transplanted patient--7 days and nights, not observing any undesirable effects. The authors recommend Naniprus infusion to be carried out very cautiously, with AP being checked every minute at the beginning at the other side until obtaining the desired and stable result. Each careless or uncontrolled administration of the preparation threatens with severe collapse. In patients with AV-fistulas reddening of the face and eyes as well as headache were observed.
在进行简短的文献调研后，作者分享了他们使用保加利亚生产的制剂Naniprus治疗肾病患者高渗性危机和急性左心功能不全的经验。患者年龄在11岁至64岁之间。在危机期间，患者的平均基础动脉压（AP）为25.2/14.5千帕，而在开始滴注后三分钟，其平均动脉压降至33.3/20.0千帕，仅三分钟后又降至平均25.1/14.7千帕（p小于0.001）。在一名高渗性危机进展中患有严重肺水肿、移植肾排斥危机的儿童中，他们连续5个昼夜输注Naniprus，在另一名移植患者中连续7个昼夜输注，未观察到任何不良影响。作者建议非常谨慎地进行Naniprus输注，开始时每分钟检查另一侧的动脉压，直到获得理想且稳定的结果。制剂的每一次粗心或无控制的给药都可能导致严重的虚脱。在患有动静脉瘘的患者中，观察到面部和眼睛发红以及头痛。
