Hirotani Masao, Sai Kou, Hirotani Seiko, Yoshikawa Takafumi
School of Pharmaceutical Sciences, Kitasato University, Minato-ku, 108-8641, Tokyo, Japan.
Phytochemistry. 2002 Mar;59(5):571-7. doi: 10.1016/s0031-9422(01)00445-9.
Four new des-A-ergostane derivatives including blazeispirols B, C, E and F were isolated from the cultured mycelia of fungus Agaricus blazei Murill and were established to be (20S, 22R, 23R, 24S)-14beta,22: 22,25-diepoxy-5-methoxy-des-A-ergosta-5,7,9,11-tetraen-23-ol; (20S, 22S, 23R, 24S)-14beta,22: 22,25-diepoxy-5-methoxy-des-A-ergosta-5,7,9-trien-23-ol; (20S, 22S, 23R, 24S)-14beta, 22: 22, 25-diepoxy-5-methoxy-des-A-ergosta-5,7,9,11-tetraene-19,23-diol and (20S, 22S, 23R, 24S)-14beta,22: 22,25-diepoxy-des-A-ergosta-5,7,9-triene-5,23-diol by comparison of extensive 1D and 2D NMR spectral data with that of blazeispirol A.
从姬松茸培养菌丝体中分离出4种新的去-A-麦角甾烷衍生物，包括巴西蘑菇醇B、C、E和F，并通过将大量一维和二维核磁共振光谱数据与巴西蘑菇醇A的数据进行比较，确定它们分别为(20S, 22R, 23R, 24S)-14β,22: 22,25-二环氧-5-甲氧基-去-A-麦角甾-5,7,9,11-四烯-23-醇；(20S, 22S, 23R, 24S)-14β,22: 22,25-二环氧-5-甲氧基-去-A-麦角甾-5,7,9-三烯-23-醇；(20S, 22S, 23R, 24S)-14β, 22: 22, 25-二环氧-5-甲氧基-去-A-麦角甾-5,7,9,11-四烯-19,23-二醇和(20S, 22S, 23R, 24S)-14β,22: 22,25-二环氧-去-A-麦角甾-5,7,9-三烯-5,23-二醇。
