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栽培灵芝的成分。

Constituents of cultivated Agaricus blazei.

机构信息

Department of Pharmacognosy, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan.

出版信息

J Nat Med. 2011 Apr;65(2):307-12. doi: 10.1007/s11418-010-0495-5. Epub 2011 Jan 18.

DOI:10.1007/s11418-010-0495-5
PMID:21240679
Abstract

Two phenylhexane derivatives (1, 2), benzoylergostane (3), N-benzoyl-L-leucine methyl ester (4), two known ergostanes, and highly degraded incisterol were isolated from fruit bodies of Agaricus blazei. Compound 3 exhibited strong cytotoxicity toward HepG2 cells (IC(50) = 6.0 ± 0.33 μM).

摘要

从巴西蘑菇的子实体中分离得到了两种苯己烷衍生物（1, 2）、苯甲酰麦角甾烷（3）、N-苯甲酰-L-亮氨酸甲酯（4）、两种已知的麦角甾烷和高度降解的incisterol。化合物 3 对 HepG2 细胞表现出很强的细胞毒性（IC50=6.0±0.33 μM）。

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本文引用的文献

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2
Blazein of a new steroid isolated from Agaricus blazei Murrill (himematsutake) induces cell death and morphological change indicative of apoptotic chromatin condensation in human lung cancer LU99 and stomach cancer KATO III cells.从姬松茸（又名巴西蘑菇）中分离出的一种新类固醇——布拉齐因，可诱导人肺癌LU99细胞和胃癌KATO III细胞发生细胞死亡以及出现指示凋亡性染色质浓缩的形态变化。
Oncol Rep. 2008 Dec;20(6):1359-61.
3
The Medicinal Mushroom Agaricus blazei Murrill: Review of Literature and Pharmaco-Toxicological Problems.
药用蘑菇巴西蘑菇（Agaricus blazei Murrill）：文献综述和药物毒理学问题。
Evid Based Complement Alternat Med. 2008 Mar;5(1):3-15. doi: 10.1093/ecam/nem007.
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An alternative medicine, Agaricus blazei, may have induced severe hepatic dysfunction in cancer patients.一种替代医学药物，姬松茸，可能在癌症患者中引发了严重的肝功能障碍。
Jpn J Clin Oncol. 2006 Dec;36(12):808-10. doi: 10.1093/jjco/hyl108. Epub 2006 Nov 14.
5
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