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迷人的呋喃甾体及其药理学特性。

Fascinating Furanosteroids and Their Pharmacological Profile.

机构信息

Centre for Applied Research, Innovation and Entrepreneurship, Lethbridge College, 3000 College Drive South, Lethbridge, AB T1K 1L6, Canada.

出版信息

Molecules. 2023 Jul 26;28(15):5669. doi: 10.3390/molecules28155669.

DOI:10.3390/molecules28155669
PMID:37570639
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10419491/
Abstract

This review article delves into the realm of furanosteroids and related isoprenoid lipids derived from diverse terrestrial and marine sources, exploring their wide array of biological activities and potential pharmacological applications. Fungi, fungal endophytes, plants, and various marine organisms, including sponges, corals, molluscs, and other invertebrates, have proven to be abundant reservoirs of these compounds. The biological activities exhibited by furanosteroids and related lipids encompass anticancer, cytotoxic effects against various cancer cell lines, antiviral, and antifungal effects. Notably, the discovery of exceptional compounds such as nakiterpiosin, malabaricol, dysideasterols, and cortistatins has revealed their potent anti-tuberculosis, antibacterial, and anti-hepatitis C attributes. These compounds also exhibit activity in inhibiting protein kinase C, phospholipase A2, and eliciting cytotoxicity against cancer cells. This comprehensive study emphasizes the significance of furanosteroids and related lipids as valuable natural products with promising therapeutic potential. The remarkable biodiversity found in both terrestrial and marine ecosystems offers an extensive resource for unearthing novel biologically active compounds, paving the way for future drug development and advancements in biomedical research. This review presents a compilation of data obtained from various studies conducted by different authors who employed the PASS software 9.1 to evaluate the biological activity of natural furanosteroids and compounds closely related to them. The utilization of the PASS software in this context offers valuable advantages, such as screening large chemical libraries, identifying compounds for subsequent experimental investigations, and gaining insights into potential biological activities based on their structural features. Nevertheless, it is crucial to emphasize that experimental validation remains indispensable for confirming the predicted activities.

摘要

这篇综述文章深入探讨了来源于不同陆地和海洋来源的呋喃甾醇和相关类异戊二烯脂质的领域，探索了它们广泛的生物活性和潜在的药理学应用。真菌、真菌内生菌、植物以及各种海洋生物，包括海绵、珊瑚、软体动物和其他无脊椎动物，已被证明是这些化合物的丰富来源。呋喃甾醇和相关脂质表现出的生物活性包括抗癌、对各种癌细胞系的细胞毒性作用、抗病毒和抗真菌作用。值得注意的是，nakiterpiosin、malabaricol、dysideasterols 和 cortistatins 等特殊化合物的发现揭示了它们在抗结核病、抗菌和抗丙型肝炎方面的强大特性。这些化合物还表现出抑制蛋白激酶 C、磷脂酶 A2 和对癌细胞产生细胞毒性的活性。这项综合研究强调了呋喃甾醇和相关脂质作为具有有前途治疗潜力的宝贵天然产物的重要性。陆地和海洋生态系统中发现的显著生物多样性为发现新型具有生物活性的化合物提供了广泛的资源，为未来的药物开发和生物医学研究的进展铺平了道路。本综述汇总了不同作者使用 PASS 软件 9.1 评估天然呋喃甾醇和与其密切相关的化合物的生物活性的各种研究中获得的数据。在这种情况下，PASS 软件的使用具有重要的优势，例如筛选大型化学库、识别化合物进行后续实验研究，并根据其结构特征了解潜在的生物活性。然而，必须强调的是，实验验证对于确认预测的活性仍然是必不可少的。

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