Gross J, Timmermann L, Kujala J, Dirks M, Schmitz F, Salmelin R, Schnitzler A
Department of Neurology, Heinrich Heine University, D-40225 Duesseldorf, Germany.
Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2299-302. doi: 10.1073/pnas.032682099.
The basic question of whether the human brain controls continuous movements intermittently is still under debate. Here we show that 6- to 9-Hz pulsatile velocity changes of slow finger movements are directly correlated to oscillatory activity in the motor cortex, which is sustained by cerebellar drive through thalamus and premotor cortex. Our findings suggest that coupling of 6- to 9-Hz oscillatory activity in the cerebello-thalamo-cortical loop represents the neural mechanism for the intermittent control of continuous movements.
人类大脑是否间歇性地控制连续运动这一基本问题仍在争论之中。在此我们表明,缓慢手指运动的6至9赫兹脉动速度变化与运动皮层的振荡活动直接相关,这种振荡活动由小脑通过丘脑和运动前皮层驱动而维持。我们的研究结果表明,小脑 - 丘脑 - 皮层环路中6至9赫兹振荡活动的耦合代表了连续运动间歇性控制的神经机制。