Milne Stewart E, James Kenneth S, Nimmo Susan, Hickey Stephen
Department of Anaesthesia, Glasgow Royal Infirmary, Glasgow, United Kingdom.
J Cardiothorac Vasc Anesth. 2002 Feb;16(1):32-6. doi: 10.1053/jcan.2002.29657.
To evaluate the effect of a fixed rate of infusion of propofol on total body oxygen consumption during the postoperative rewarming phase after cardiopulmonary bypass.
Prospective, randomized, controlled study.
Cardiac intensive care unit, university hospital.
Twenty-four male and female patients undergoing elective first-time coronary artery bypass graft surgery.
Total body oxygen consumption was measured using a pulmonary artery catheter and thermodilution during postoperative rewarming. Twelve patients had propofol infused at 2 mg/kg/h for 4 hours or until rewarmed.
Total body oxygen consumption was reduced in the propofol group compared with the control group. Oxygen consumption was a median of 30.0 mL/min/m(2) less in the patients receiving propofol (p = 0.01). One patient receiving propofol shivered compared with 4 in the control group (p = 0.14).
Administration of propofol during postoperative rewarming reduces total body oxygen consumption and may reduce shivering.
评估在体外循环术后复温阶段，丙泊酚固定输注速率对全身氧耗的影响。
前瞻性、随机、对照研究。
大学医院心脏重症监护病房。
24例择期首次接受冠状动脉旁路移植术的男性和女性患者。
术后复温期间，使用肺动脉导管和热稀释法测量全身氧耗。12例患者以2mg/kg/h的速率输注丙泊酚4小时或直至复温。
与对照组相比，丙泊酚组的全身氧耗降低。接受丙泊酚治疗的患者氧耗中位数比对照组少30.0mL/min/m²（p = 0.01）。接受丙泊酚治疗的1例患者出现寒战，而对照组有4例（p = 0.14）。
术后复温期间给予丙泊酚可降低全身氧耗，并可能减少寒战。
