一些A环和D环稠合的甾体吡唑、异恶唑和嘧啶的合成。
Synthesis of some A- and D-ring fused steroidal pyrazoles, isoxazoles and pyrimidines.
作者信息
Laitonjam Warjeet S, Rajkumar Tombisana S, Chingakham Brajakishor S
机构信息
Department of Chemistry, Manipur University, Canchipur-795 003, Manipur, India.
出版信息
Steroids. 2002 Mar;67(3-4):203-9. doi: 10.1016/s0039-128x(01)00146-5.
The preparation of steroidal heterocycles containing pyrazole, isoxazole and pyrimidine rings fused to the 2,3- and 16,17-positions of the steroid nucleus is described. These were prepared by the reaction of hydrazine, hydroxylamine and guanidine, respectively, with 2-ethoxymethylene-3-oxo- or 16-ethoxymethylene-17-oxo- or 2-bis(methylthio)methylene-3-oxo- or 16-bis(methylthio)methylene-17-oxo-steroids.
本文描述了甾体杂环化合物的制备方法，这些杂环化合物含有与甾体核2,3-位和16,17-位稠合的吡唑、异恶唑和嘧啶环。它们分别通过肼、羟胺和胍与2-乙氧基亚甲基-3-氧代-或16-乙氧基亚甲基-17-氧代-或2-双（甲硫基）亚甲基-3-氧代-或16-双（甲硫基）亚甲基-17-氧代-甾体的反应来制备。
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