一种通过嘧啶衍生物环化反应合成取代的 2-硫代喹唑啉-4-酮的新的简便方法。
A new and facile synthetic approach to substituted 2-thioxoquinazolin-4-ones by the annulation of a pyrimidine derivative.
机构信息
Department of Chemistry, Manipur University, Canchipur 795 003, Manipur, India.
出版信息
Beilstein J Org Chem. 2010 Nov 9;6:1056-60. doi: 10.3762/bjoc.6.120.
Abstract
A new and facile synthesis of 2-thioxoquinazolin-4-ones by introducing a benzenoid system in the pyrimidine moiety by reacting ethoxymethylene derivatives of 1,3-diarylthiobarbituric acids (DTBA) with active methylene compounds, such as malononitrile and ethyl cyanoacetate, in presence of ZnCl₂ has been developed.
摘要
通过在 1,3-二芳基硫代巴比妥酸（DTBA）的乙氧亚甲基衍生物与丙二腈和氰基乙酸乙酯等活性亚甲基化合物之间引入苯并体系，在 ZnCl₂存在下，开发了一种新的简便的 2-硫代喹唑啉-4-酮合成方法。
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