5-羟色胺、多巴胺和去甲肾上腺素对豚鼠小肠黏膜下神经丛神经元的某些作用。
Some effects of 5-hydroxytryptamine, dopamine and noradrenaline on neurones in the submucous plexus of guinea-pig small intestine.
作者信息
Hirst G D, Silinsky E M
出版信息
J Physiol. 1975 Oct;251(3):817-32. doi: 10.1113/jphysiol.1975.sp011124.
Abstract
- Responses to the iontophoretic application of 5-hydroxytryptamine (5-HT), dopamine and noradrenaline were examined in neurones of the submucous plexus of guinea-pig small intestine. 2. Every neurone was excited by 5-HT. 3. In a proportion of cells, dopamine or noradrenaline caused an increase in membrane potential. This response was only observed in cells which received in inhibitory innervation. The responses closely resembled inhibitory synaptic potentials evoked by transmural stimulation. 4. Both inhibitory synaptic potentials and inhibitory responses to dopamine and noradrenaline were blocked by methysergide. 5. It seems possible that these two catecholamines may interact with similar receptors to those activated by inhibitory transmitter.
摘要
- 在豚鼠小肠黏膜下神经丛的神经元中检测了对离子电渗法施加5-羟色胺（5-HT）、多巴胺和去甲肾上腺素的反应。2. 每个神经元都被5-HT兴奋。3. 在一部分细胞中，多巴胺或去甲肾上腺素引起膜电位升高。这种反应仅在接受抑制性神经支配的细胞中观察到。这些反应与经壁刺激诱发的抑制性突触电位非常相似。4. 抑制性突触电位以及对多巴胺和去甲肾上腺素的抑制性反应均被麦角新碱阻断。5. 这两种儿茶酚胺可能与被抑制性递质激活的类似受体相互作用，这似乎是有可能的。
相似文献
1
Some effects of 5-hydroxytryptamine, dopamine and noradrenaline on neurones in the submucous plexus of guinea-pig small intestine.5-羟色胺、多巴胺和去甲肾上腺素对豚鼠小肠黏膜下神经丛神经元的某些作用。
J Physiol. 1975 Oct;251(3):817-32. doi: 10.1113/jphysiol.1975.sp011124.
2
Slow postsynaptic potentials in neurones of submucous plexus of guinea-pig caecum and their mimicry by noradrenaline and various peptides.豚鼠盲肠黏膜下神经丛神经元中的慢突触后电位及其去甲肾上腺素和多种肽类的模拟作用
Neuroscience. 1985 Dec;16(4):1057-68. doi: 10.1016/0306-4522(85)90116-2.
3
Synaptic potentials recorded from neurones of the submucous plexus of guinea-pig small intestine.从豚鼠小肠黏膜下神经丛神经元记录到的突触电位。
J Physiol. 1975 Jul;249(2):369-85. doi: 10.1113/jphysiol.1975.sp011020.
4
Inhibitory synaptic potentials resulting from alpha 2-adrenoceptor activation in guinea-pig submucous plexus neurones.豚鼠黏膜下神经丛神经元中α2 -肾上腺素能受体激活所产生的抑制性突触电位。
J Physiol. 1985 Jan;358:17-33. doi: 10.1113/jphysiol.1985.sp015537.
5
Electrophysiological characterization of functionally distinct 5-hydroxytryptamine receptors on guinea-pig submucous plexus.豚鼠黏膜下神经丛中功能不同的5-羟色胺受体的电生理特性
Neuroscience. 1988 Jan;24(1):283-95. doi: 10.1016/0306-4522(88)90331-4.
6
On the transmitter function of 5-hydroxytryptamine at excitatory and inhibitory monosynaptic junctions.5-羟色胺在兴奋性和抑制性单突触连接处的递质功能
J Physiol. 1974 Dec;243(2):457-81. doi: 10.1113/jphysiol.1974.sp010762.
7
Inhibitory synaptic potentials recorded from mammalian neurones prolonged by blockade of noradrenaline uptake.通过阻断去甲肾上腺素摄取延长从哺乳动物神经元记录到的抑制性突触电位。
J Physiol. 1987 Jan;382:87-103. doi: 10.1113/jphysiol.1987.sp016357.
8
Synaptic inputs to immunohistochemically identified neurones in the submucous plexus of the guinea-pig small intestine.豚鼠小肠黏膜下神经丛中经免疫组织化学鉴定的神经元的突触输入
J Physiol. 1986 Dec;381:465-82. doi: 10.1113/jphysiol.1986.sp016339.
9
Actions of galanin on neurotransmission in the submucous plexus of guinea pig small intestine.甘丙肽对豚鼠小肠黏膜下神经丛神经传递的作用。
Eur J Pharmacol. 2003 Jun 13;471(1):49-58. doi: 10.1016/s0014-2999(03)01798-9.
10
Intrinsic and extrinsic inhibitory synaptic inputs to submucous neurones of the guinea-pig small intestine.豚鼠小肠黏膜下神经元的内在和外在抑制性突触输入。
J Physiol. 1988 Apr;398:371-90. doi: 10.1113/jphysiol.1988.sp017048.
引用本文的文献
1
An In Vitro Approach to Studying the Microbial Community and Impact of Pre and Probiotics under Anorexia Nervosa Related Dietary Restrictions.在神经性厌食症相关饮食限制下研究微生物群落和益生菌及预益生菌影响的体外方法。
Nutrients. 2021 Dec 13;13(12):4447. doi: 10.3390/nu13124447.
2
Neurotransmitters: The Critical Modulators Regulating Gut-Brain Axis.神经递质：调节肠-脑轴的关键调节因子。
J Cell Physiol. 2017 Sep;232(9):2359-2372. doi: 10.1002/jcp.25518. Epub 2017 Apr 10.
3
Gastrointestinal Parasites and the Neural Control of Gut Functions.胃肠道寄生虫与肠道功能的神经控制
Front Cell Neurosci. 2015 Nov 25;9:452. doi: 10.3389/fncel.2015.00452. eCollection 2015.
4
5-HT(1A), SST(1), and SST(2) receptors mediate inhibitory postsynaptic potentials in the submucous plexus of the guinea pig ileum.5-HT(1A)、SST(1)和 SST(2)受体介导豚鼠回肠黏膜下神经丛中的抑制性突触后电位。
Am J Physiol Gastrointest Liver Physiol. 2010 Mar;298(3):G384-94. doi: 10.1152/ajpgi.00438.2009. Epub 2009 Dec 10.
5
Physiological modulation of intestinal motility by enteric dopaminergic neurons and the D2 receptor: analysis of dopamine receptor expression, location, development, and function in wild-type and knock-out mice.肠道多巴胺能神经元和D2受体对肠道运动的生理调节：野生型和基因敲除小鼠中多巴胺受体的表达、定位、发育及功能分析
J Neurosci. 2006 Mar 8;26(10):2798-807. doi: 10.1523/JNEUROSCI.4720-05.2006.
6
Enteric dopaminergic neurons: definition, developmental lineage, and effects of extrinsic denervation.肠多巴胺能神经元：定义、发育谱系及外在去神经支配的影响。
J Neurosci. 2004 Feb 11;24(6):1330-9. doi: 10.1523/JNEUROSCI.3982-03.2004.
7
Noradrenaline as a presynaptic inhibitory neurotransmitter in ganglia of the guinea-pig gall-bladder.去甲肾上腺素作为豚鼠胆囊神经节中的一种突触前抑制性神经递质。
J Physiol. 1993 Feb;461:387-402. doi: 10.1113/jphysiol.1993.sp019519.
8
Characterization of 5-hydroxytryptamine receptors mediating mucosal secretion in guinea-pig ileum.介导豚鼠回肠黏膜分泌的5-羟色胺受体的特性研究
Br J Pharmacol. 1994 Apr;111(4):1240-4. doi: 10.1111/j.1476-5381.1994.tb14878.x.
9
Substance P effects on blood flow, fluid transport and vasoactive intestinal polypeptide release in the feline small intestine.P物质对猫小肠血流、液体转运及血管活性肠肽释放的影响。
J Physiol. 1995 Mar 15;483 ( Pt 3)(Pt 3):727-34. doi: 10.1113/jphysiol.1995.sp020617.
10
Multiple actions of 5-hydroxytryptamine on myenteric neurones of the guinea-pig ileum.5-羟色胺对豚鼠回肠肌间神经元的多种作用。
J Physiol. 1980 Jul;304:459-70. doi: 10.1113/jphysiol.1980.sp013336.
本文引用的文献
1
On the localization of acetylcholine receptors.关于乙酰胆碱受体的定位
J Physiol. 1955 Apr 28;128(1):157-81. doi: 10.1113/jphysiol.1955.sp005297.
2
Synaptic transmission in the sympathetic ganglion of the frog.青蛙交感神经节中的突触传递。
J Physiol. 1963 Jul;167(2):355-73. doi: 10.1113/jphysiol.1963.sp007155.
3
5-hydroxytryptamine antagonists.5-羟色胺拮抗剂
Pharmacol Rev. 1961 Sep;13:399-439.
4
A study of supersensitivity in denervated mammalian skeletal muscle.失神经支配的哺乳动物骨骼肌超敏反应的研究。
J Physiol. 1959 Jun 23;147(1):178-93. doi: 10.1113/jphysiol.1959.sp006233.
5
An electrophysiological study of 5-hydroxytryptamine receptors of neurones in the molluscan nervous system.软体动物神经系统中神经元5-羟色胺受体的电生理研究。
J Physiol. 1966 Aug;185(3):684-700. doi: 10.1113/jphysiol.1966.sp008010.
6
Presynaptic inhibition at mammalian peripheral synapse?哺乳动物外周突触处的突触前抑制？
Nature. 1974 Aug 2;250(465):430-1. doi: 10.1038/250430a0.
7
Conductance changes associated with the secretory potential in the cockroach salivary gland.蟑螂唾液腺中与分泌电位相关的电导变化。
J Physiol. 1974 Feb;236(3):723-31. doi: 10.1113/jphysiol.1974.sp010462.
8
Intracellular recording from the myenteric plexus of the guinea-pig ileum.豚鼠回肠肌间神经丛的细胞内记录。
J Physiol. 1973 Jun;231(3):471-91. doi: 10.1113/jphysiol.1973.sp010244.
9
Inhibitory and excitatory effects of dopamine on Aplysia neurones.多巴胺对海兔神经元的抑制和兴奋作用。
J Physiol. 1972 Aug;225(1):173-209. doi: 10.1113/jphysiol.1972.sp009933.
10
Dopamine receptors in cockroach salivary gland cells.蟑螂唾液腺细胞中的多巴胺受体。
Nat New Biol. 1973 Sep 12;245(141):63. doi: 10.1038/newbio245063a0.
Zotero 插件