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5-羟色胺、多巴胺和去甲肾上腺素对豚鼠小肠黏膜下神经丛神经元的某些作用。

Some effects of 5-hydroxytryptamine, dopamine and noradrenaline on neurones in the submucous plexus of guinea-pig small intestine.

作者信息

Hirst G D, Silinsky E M

出版信息

J Physiol. 1975 Oct;251(3):817-32. doi: 10.1113/jphysiol.1975.sp011124.

DOI:10.1113/jphysiol.1975.sp011124
PMID:1185684
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1348419/
Abstract
  1. Responses to the iontophoretic application of 5-hydroxytryptamine (5-HT), dopamine and noradrenaline were examined in neurones of the submucous plexus of guinea-pig small intestine. 2. Every neurone was excited by 5-HT. 3. In a proportion of cells, dopamine or noradrenaline caused an increase in membrane potential. This response was only observed in cells which received in inhibitory innervation. The responses closely resembled inhibitory synaptic potentials evoked by transmural stimulation. 4. Both inhibitory synaptic potentials and inhibitory responses to dopamine and noradrenaline were blocked by methysergide. 5. It seems possible that these two catecholamines may interact with similar receptors to those activated by inhibitory transmitter.
摘要
  1. 在豚鼠小肠黏膜下神经丛的神经元中检测了对离子电渗法施加5-羟色胺（5-HT）、多巴胺和去甲肾上腺素的反应。2. 每个神经元都被5-HT兴奋。3. 在一部分细胞中，多巴胺或去甲肾上腺素引起膜电位升高。这种反应仅在接受抑制性神经支配的细胞中观察到。这些反应与经壁刺激诱发的抑制性突触电位非常相似。4. 抑制性突触电位以及对多巴胺和去甲肾上腺素的抑制性反应均被麦角新碱阻断。5. 这两种儿茶酚胺可能与被抑制性递质激活的类似受体相互作用，这似乎是有可能的。

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本文引用的文献

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