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用于治疗中风的形状记忆聚合物微致动器的光热特性

Photothermal properties of shape memory polymer micro-actuators for treating stroke.

作者信息

Maitland Duncan J, Metzger Melodie F, Schumann Daniel, Lee Abraham, Wilson Thomas S

机构信息

Medical Technology Program, Lawrence Livermore National Laboratory, Livermore, California 94550, USA.

出版信息

Lasers Surg Med. 2002;30(1):1-11. doi: 10.1002/lsm.10007.

Abstract

BACKGROUND AND OBJECTIVES

In this paper the photothermal engineering issues of novel shape memory polymer (SMP) microactuators for treating stroke are presented. The engineering issues for using lasers to heat and subsequently actuate these SMP devices are presented in order to provide design criteria and guidelines for intravascular, laser activated SMP devices.

MATERIALS AND METHODS

A total of three devices will be presented: two interventional ischemic stroke devices (coil and umbrella) and one device for releasing embolic coils (microgripper). The optical properties of SMP, methods for coupling laser light into SMP, heating distributions in the SMP devices, and the impact of operating the thermally activated material in a blood vessel are presented.

RESULTS

Actuating the devices requires device temperatures in the range of 65-85 degrees C. Attaining these temperatures under flow conditions requires critical engineering of the SMP optical properties, optical coupling into the SMP, and device geometries.

CONCLUSION

Laser-activated SMP devices are a unique combination of laser-tissue and biomaterial technologies. Successful deployment of the microactuator requires well-engineered coupling of the light from the diffusing fiber through the blood into the SMP.

摘要

背景与目的

本文介绍了用于治疗中风的新型形状记忆聚合物(SMP)微驱动器的光热工程问题。文中阐述了使用激光加热并随后驱动这些SMP装置的工程问题,以便为血管内激光激活的SMP装置提供设计标准和指导方针。

材料与方法

共展示三种装置:两种用于治疗缺血性中风的介入装置(线圈和伞)以及一种用于释放栓塞线圈的装置(微型夹具)。介绍了SMP的光学特性、将激光耦合到SMP中的方法、SMP装置中的热分布以及在血管中操作热激活材料的影响。

结果

驱动这些装置需要装置温度在65 - 85摄氏度范围内。在流动条件下达到这些温度需要对SMP的光学特性、光耦合到SMP中的方式以及装置几何形状进行关键设计。

结论

激光激活的SMP装置是激光组织技术和生物材料技术的独特结合。微驱动器的成功应用需要精心设计将来自扩散光纤的光通过血液耦合到SMP中的过程。

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