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用于医疗设备磁驱动的感应加热形状记忆聚合物。

Inductively heated shape memory polymer for the magnetic actuation of medical devices.

作者信息

Buckley Patrick R, McKinley Gareth H, Wilson Thomas S, Small Ward, Benett William J, Bearinger Jane P, McElfresh Michael W, Maitland Duncan J

机构信息

Lawrence Livermore National Laboratory, Livermore, CA 94550, USA.

出版信息

IEEE Trans Biomed Eng. 2006 Oct;53(10):2075-83. doi: 10.1109/TBME.2006.877113.

Abstract

Presently, there is interest in making medical devices such as expandable stents and intravascular microactuators from shape memory polymer (SMP). One of the key challenges in realizing SMP medical devices is the implementation of a safe and effective method of thermally actuating various device geometries in vivo. A novel scheme of actuation by Curie-thermoregulated inductive heating is presented. Prototype medical devices made from SMP loaded with nickel zinc ferrite ferromagnetic particles were actuated in air by applying an alternating magnetic field to induce heating. Dynamic mechanical thermal analysis was performed on both the particle-loaded and neat SMP materials to assess the impact of the ferrite particles on the mechanical properties of the samples. Calorimetry was used to quantify the rate of heat generation as a function of particle size and volumetric loading of ferrite particles in the SMP. These tests demonstrated the feasibility of SMP actuation by inductive heating. Rapid and uniform heating was achieved in complex device geometries and particle loading up to 10% volume content did not interfere with the shape recovery of the SMP.

摘要

目前,人们对用形状记忆聚合物(SMP)制造诸如可膨胀支架和血管内微致动器等医疗设备很感兴趣。实现SMP医疗设备的关键挑战之一是在体内实施一种安全有效的方法来热驱动各种设备几何形状。本文提出了一种通过居里温度调节感应加热进行驱动的新方案。由负载镍锌铁氧体铁磁颗粒的SMP制成的原型医疗设备在空气中通过施加交变磁场来诱导加热从而被驱动。对负载颗粒的SMP材料和纯SMP材料都进行了动态机械热分析,以评估铁氧体颗粒对样品机械性能的影响。量热法用于量化作为铁氧体颗粒粒径和体积负载量函数的发热速率。这些测试证明了通过感应加热驱动SMP的可行性。在复杂的设备几何形状中实现了快速且均匀的加热,并且高达10%体积含量的颗粒负载不会干扰SMP的形状恢复。

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