白头翁中的新羽扇豆烷糖苷。

New lupane glycosides from Pulsatilla chinensis.

作者信息

Ye Wencai, Zhang Qingwen, Hsiao Wendy W, Zhao Shouxun, Che Chun-Tao

出版信息

Planta Med. 2002 Feb;68(2):183-6. doi: 10.1055/s-2002-20254.

DOI:10.1055/s-2002-20254

Abstract

Two new lupane glycosides along with five known triterpenoids were isolated from the roots of Pulsatilla chinensis (Ranunculaceae). The structures of the new glycosides were determined to be 3-O-beta-D-glucopyranosyl(1-->3)-alpha-L-arabinopyranosyl-23-hydroxybetulinic acid 28-O-alpha-L-rhamnopyranosyl(1-->4)-beta-D-glucopyranosyl(1-->6)-beta-D-glucopyranosyl ester (pulsatilloside D, 6) and 3-O-[beta-D-glucopyranosyl(1-->4)][alpha-L-rhamnopyranosyl(1-->2)]-alpha-L-arabinopyranosyl-23-hydroxybetulinic acid 28-O-alpha-L-rhamnopyranosyl(1-->4)-beta-D-glucopyranosyl(1-->6)-beta-D-glucopyranosyl ester (pulsatilloside E, 7) by spectroscopic analysis and chemical methods. The compounds were evaluated for cytotoxic activities against K-562 human leukemia and HeLa cells.

摘要

从白头翁（毛茛科）的根部分离出两种新的羽扇豆烷糖苷以及五种已知的三萜类化合物。通过光谱分析和化学方法确定新糖苷的结构为3-O-β-D-吡喃葡萄糖基（1→3）-α-L-吡喃阿拉伯糖基-23-羟基白桦酸28-O-α-L-吡喃鼠李糖基（1→4）-β-D-吡喃葡萄糖基（1→6）-β-D-吡喃葡萄糖基酯（白头翁皂苷D，6）和3-O-[β-D-吡喃葡萄糖基（1→4）][α-L-吡喃鼠李糖基（1→2）]-α-L-吡喃阿拉伯糖基-23-羟基白桦酸28-O-α-L-吡喃鼠李糖基（1→4）-β-D-吡喃葡萄糖基（1→6）-β-D-吡喃葡萄糖基酯（白头翁皂苷E，7）。评估了这些化合物对K-562人白血病细胞和HeLa细胞的细胞毒性活性。