来自中华野木瓜的五种新的双糖链三萜皂苷。

Five new bidesmoside triterpenoid saponins from Stauntonia chinensis.

作者信息

Hao Gao, Zhao Wang, Lei Yang, Yang Yu, Zhi-Hong Yao, Nai-Li Wang, Guang-Xiong Zhou, Wen-Cai Ye, Xin-Sheng Yao

机构信息

Key Lab for New Drugs Research of TCM, Shenzhen Research Institute of Tsinghua University, Shenzhen 518055, PR China.

出版信息

Magn Reson Chem. 2008 Jul;46(7):630-7. doi: 10.1002/mrc.2222.

DOI:10.1002/mrc.2222

PMID:18393259

Abstract

Eleven triterpenoid saponins (1-11) were isolated from Stauntonia chinensis DC. (Lardizabalaceae), including five new compounds, yemuoside YM(21-25) (1-3, 6, 7) structures of which were elucidated by chemical methods and a combination of MS, 1D- and 2D- NMR experiments including DEPT, (1)H--(1)H COSY, HSQC, HMBC, TOCSY, and NOESY as 3-O-alpha-L-arabinopyranosyl-(1 --> 3)-[alpha-L-rhamnopyranosyl-(1 --> 2)-]alpha-L-arabinopyranosyl-akebonicacid-28-O-alpha-L-rhamnopyranosyl-(1 --> 4)-beta-D-glucopyranosyl-(1 --> 6)-beta-D-glucopyranosyl ester (1), 3-O-beta-D-xylopyranosyl-(1 --> 3)-alpha-L-rhamnopyranosyl-(1 --> 2)-alpha-L-arabinopyranosyl-akebonic acid-28-O-alpha-L-rhamnopyranosyl-(1 --> 4)-beta-D-glucopyranosyl-(1 --> 6)-beta-D-glucopyranosyl ester (2), 3-O-beta-D-glucopyranosyl-(1 --> 3)-alpha-L-arabinopyranosyl-akebonic acid-28-O-alpha-L-rhamnopyranosyl-(1 --> 4)-beta-D-glucopyranosyl-(1 --> 6)-beta-D-glucopyranosyl ester (3), 3-O-alpha-L-arabinopyranosyl-(1 --> 3)-[alpha-L-rhamnopyranosyl-(1 --> 2)-]alpha-L-arabinopyranosyl-akebonic acid-28-O-beta-D-glucopyranosyl-(1 --> 6)-beta-D-glucopyranosyl ester (6), 3-O-alpha-L-arabinopyranosyl-(1 --> 3)-[alpha-L-arabinopyranosyl-(1 --> 2)-]alpha-L-arabinopyranosyl-akebonic acid-28-O-beta-D-glucopyranosyl-(1 --> 6)-beta-D-glucopyranosyl ester (7).

摘要

从木通科植物中华野木瓜（Stauntonia chinensis DC.）中分离得到11个三萜皂苷（1-11），其中包括5个新化合物，野木瓜苷YM(21-25)（1-3、6、7），其结构通过化学方法以及质谱、一维和二维核磁共振实验（包括DEPT、¹H-¹H COSY、HSQC、HMBC、TOCSY和NOESY）得以阐明，分别为3-O-α-L-阿拉伯吡喃糖基-(1→3)-[α-L-鼠李吡喃糖基-(1→2)-]α-L-阿拉伯吡喃糖基-秋生酸-28-O-α-L-鼠李吡喃糖基-(1→4)-β-D-吡喃葡萄糖基-(1→6)-β-D-吡喃葡萄糖基酯（1）、3-O-β-D-木吡喃糖基-(1→3)-α-L-鼠李吡喃糖基-(1→2)-α-L-阿拉伯吡喃糖基-秋生酸-28-O-α-L-鼠李吡喃糖基-(1→4)-β-D-吡喃葡萄糖基-(1→6)-β-D-吡喃葡萄糖基酯（2）、3-O-β-D-吡喃葡萄糖基-(1→3)-α-L-阿拉伯吡喃糖基-秋生酸-28-O-α-L-鼠李吡喃糖基-(1→4)-β-D-吡喃葡萄糖基-(1→6)-β-D-吡喃葡萄糖基酯（3）、3-O-α-L-阿拉伯吡喃糖基-(1→3)-[α-L-鼠李吡喃糖基-(1→2)-]α-L-阿拉伯吡喃糖基-秋生酸-28-O-β-D-吡喃葡萄糖基-(1→6)-β-D-吡喃葡萄糖基酯（6）、3-O-α-L-阿拉伯吡喃糖基-(1→3)-[α-L-阿拉伯吡喃糖基-(1→2)-]α-L-阿拉伯吡喃糖基-秋生酸-28-O-β-D-吡喃葡萄糖基-(1→6)-β-D-吡喃葡萄糖基酯（7）。