Teppo H, Koivunen P, Sipilä S, Jokinen K, Hyrynkangas K, Läärä E, Pukkala E, Sovio U, Alho O P
Department of Otorhinolaryngology, University of Oulu, Finland.
Acta Oncol. 2001;40(7):791-5. doi: 10.1080/02841860152703391.
The decreasing incidence rate and improvement in survival of laryngeal cancer patients in Finland are exceptions among western countries. A descriptive study of these trends was conducted including both nationwide population-based cancer registry data with 5 766 patients diagnosed in 1956-1995 and regional hospital-based data from Northern Finland, allowing classification into supraglottic and glottic cancers, with 353 patients diagnosed in 1976-1995. In Finland, the age-adjusted incidence rate among males decreased from 6.5 per 100 000 in 1956-1965 to 3.5 in 1986-1995, while in females the rate remained around 0.3 per 100 000. The rates in Northern Finland were slightly higher and the supraglottic to glottic incidence ratio diminished from 1.4:1 in 1976-1985 to 0.5:1 in 1986-1995. The 5-year relative survival rate improved in both Northern Finland and the whole country, most noticeably among males and the elderly. In the data from Northern Finland, the survival rate was more favourable in glottic (80%) than in supraglottic cancer (64%). Considering the marked decrease in the incidence of the less favourable supraglottic disease, the observed improvement in survival was small.
在西方国家中，芬兰喉癌患者发病率的下降及生存率的提高是个例外。我们开展了一项关于这些趋势的描述性研究，纳入了1956年至1995年期间全国基于人群的癌症登记数据（共5766例确诊患者）以及芬兰北部基于地区医院的数据（可分为声门上癌和声门癌，1976年至1995年期间有353例确诊患者）。在芬兰，男性年龄调整发病率从1956年至1965年的每10万例6.5例降至1986年至1995年的3.5例，而女性发病率则维持在每10万例0.3例左右。芬兰北部的发病率略高，声门上癌与声门癌的发病率之比从1976年至1985年的1.4:1降至1986年至1995年的0.5:1。芬兰北部和全国的5年相对生存率均有所提高，在男性和老年人中最为显著。在芬兰北部的数据中，声门癌患者的生存率（80%）高于声门上癌患者（64%）。鉴于预后较差的声门上疾病发病率显著下降，观察到的生存率改善幅度较小。
