Kohler E, Sheth K J, Good T A
Acta Diabetol Lat. 1979 Jul-Sep;16(3):247-55. doi: 10.1007/BF02629119.
Two lysosomal glycohydrolases, beta-galactosidase and beta-N-hexosaminidase which have been associated with kidney disease were measured in the urine of 110 youngsters with juvenile diabetes mellitus. The mean enzyme excretions in the diabetic group were intermediate between those of normal youngsters and those with active renal disease. Three youngsters with known kidney disease had elevations comparable to others in the diabetic group but no direct correlation could be shown between enzyme elevations and proteinuria or Addis count abnormalities. Positive correlations were seen between enzyme levels and indices of metabolic balance including blood sugar, cholesterol and triglycerides but not with urine sugar or ketones. Duration and estimated stage and control of diabetes also correlated with the urinary enzymes. These preliminary studies are consistent with the possibility that the excretion of these enzymes reflects the ongoing renal damage which occurs in most juvenile diabetics.
在110名青少年糖尿病患者的尿液中检测了两种与肾脏疾病相关的溶酶体糖水解酶，即β-半乳糖苷酶和β-N-己糖胺酶。糖尿病组的平均酶排泄量介于正常青少年和患有活动性肾脏疾病的青少年之间。三名已知患有肾脏疾病的青少年的酶水平升高程度与糖尿病组中的其他患者相当，但酶水平升高与蛋白尿或艾迪斯计数异常之间未显示出直接相关性。酶水平与包括血糖、胆固醇和甘油三酯在内的代谢平衡指标呈正相关，但与尿糖或酮体无关。糖尿病的病程、估计分期和控制情况也与尿酶相关。这些初步研究表明，这些酶的排泄可能反映了大多数青少年糖尿病患者正在发生的肾脏损伤。
