Bomback F M, Nakagawa S, Kumin S, Nitowsky H M
Diabetes. 1976 May;25(5):420-7. doi: 10.2337/diab.25.5.420.
Studies have been carried out on activities of lysosomal beta-N-acetylhexosaminidase (hex), beta-galactosidase (beta-gal), alpha-glucosidase (alpha-glu), and acid phosphatase (AP) in serum and urine from patients with juvenile diabetes and matched controls. There is a large increase in blood and urinary hex activity (the former presenting three distinct patterns of abnormality), a moderate increase in urinary beta-gal, and a small increase in urinary alpha-glu activity, but no elevation of blood or urinary AP in the diabetics. Urinary alpha-glu activity in the diabetics shows striking inhibition by glucose, and this may reflect a similar phenomenon in vivo. Although glycohydrolase activities are elevated in patients with no detectable microangiopathy, more striking changes may be observed in patients with severe small-vessel disease. These alterations may be associated with increased glycoprotein catabolism in the diabetic, an area in need of further studies in the human and experimental diabetic animal.
对青少年糖尿病患者及其匹配对照组的血清和尿液中的溶酶体β-N-乙酰己糖胺酶（己糖胺酶）、β-半乳糖苷酶（β-半乳糖苷酶）、α-葡萄糖苷酶（α-葡萄糖苷酶）和酸性磷酸酶（AP）活性进行了研究。糖尿病患者血液和尿液中的己糖胺酶活性大幅增加（前者呈现三种不同的异常模式），尿液中的β-半乳糖苷酶适度增加，尿液中的α-葡萄糖苷酶活性小幅增加，但糖尿病患者血液或尿液中的AP无升高。糖尿病患者尿液中的α-葡萄糖苷酶活性受到葡萄糖的显著抑制，这可能反映了体内的类似现象。虽然在无微血管病变可检测的患者中糖水解酶活性升高，但在患有严重小血管疾病的患者中可能观察到更显著的变化。这些改变可能与糖尿病患者糖蛋白分解代谢增加有关，这是一个需要在人类和实验性糖尿病动物中进一步研究的领域。
