Hu X, Zhu F, Wang H, Chen S, Wang G, Sun J, Hua C, Yang H
Jiangsu Provincial Sanitary and Health Center, Nanjing 210009, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2000 May;34(3):150-2.
To demonstrate the clinical manifestations of S. suis infectious syndrome; to study the characteristics of causative organism and its source.
25 cases of unknown causes of food poisoning were identified in the central area of Jiangsu province, China in July 1998. Biological specimens was collected in some patients, and the causative organism was isolated using a number of different culture medium. Isolated organisms were identified by serum antibody tests, API biochemical tests, drug sensitivity tests and animal model experiments. The human born strains and the pig born strains were compared by RAPD technique. Epidemiological methods were applied to trace the source of causative organisms.
Cases were clinically categorized into two types: Streptococcal toxic shock syndrome (STSS) and streptococcal meningitis syndrome (SMS). Three strains of streptococci were isolated respectively from the blood and cerebrospinal fluid of 6 cases. All these 6 strains were confirmed to be S. suis type 2 by culture characteristics, morphology, biochemical characteristics, serum antibody tests and fatty acid profile analysis. Animal model experiment showed that these strains were sensitive to rabbits and pigs, but not to rats. RAPD fingerprint test revealed an identity between human born and pig born strains.
The aetiological agent of these human cases was S. suis type 2. Human cases were contracted by direct contact with the infected pigs or the corpse of infected pigs.
阐述猪链球菌感染综合征的临床表现；研究致病病原体的特征及其来源。
1998年7月在中国江苏省中部地区确认了25例不明原因的食物中毒病例。采集了部分患者的生物标本，使用多种不同培养基分离致病病原体。通过血清抗体检测、API生化检测、药敏试验和动物模型实验对分离出的病原体进行鉴定。采用RAPD技术比较人源菌株和猪源菌株。应用流行病学方法追踪致病病原体的来源。
病例在临床上分为两型：链球菌中毒性休克综合征（STSS）和链球菌脑膜炎综合征（SMS）。分别从6例患者的血液和脑脊液中分离出3株链球菌。通过培养特征、形态学、生化特征、血清抗体检测和脂肪酸谱分析，确认这6株菌均为2型猪链球菌。动物模型实验表明，这些菌株对兔和猪敏感，但对大鼠不敏感。RAPD指纹图谱检测显示人源菌株和猪源菌株具有一致性。
这些人类病例的病原体为2型猪链球菌。人类病例是通过直接接触感染猪或感染猪的尸体而感染的。
