Goldman Mitchel P, Roberts Thomas L, Skover Greg, Lettieri John T, Fitzpatrick Richard E
Dermatology Associates of San Diego County, Inc., 9850 Genesee Ave. Suite 480, La Jolla, CA 92037, USA.
J Am Acad Dermatol. 2002 Mar;46(3):399-407. doi: 10.1067/mjd.2002.118358.
Laser resurfacing is a popular procedure to improve the physical signs of photoaging. In addition to improvements in treatment modalities, optimizing posttreatment regimens will enhance patient care.
Our purpose was to evaluate the efficacy of two forms of wound care for the face after laser abrasion.
Forty-two patients received full-face laser resurfacing at two clinics by using either the UltraPulse carbon dioxide (CO(2)) laser (Coherent Laser Corp, Palo Alto, Calif) alone or followed by an erbium:YAG laser (Derma-20, ESC Sharplan, Inc, Needham, Mass) and/or a blended CO(2)/Er:YAG laser (Derma-K, ESC Sharplan) or a variable pulse erbium:YAG laser (Contour, Sciton Laser Corp, Palo Alto). Twenty-one patients were randomly assigned to a postoperative regimen including Silon-TSR (Bio Med Sciences, Inc, Allentown, Pa) for the first 2 to 3 days after laser resurfacing, followed by Aquaphor ointment (Beiersdorf, Charlotte, NC) to complete the first 2 weeks. The other 21 patients received the resurfacing recovery system (RRS, Neutrogena, Los Angeles, Calif) following a specific regimen. The system includes Fibracol wound dressing (Johnson & Johnson, Skillman, NJ) for 2 days, followed by a hydrogel dressing for 1 to 2 days, followed by an ointment to complete the first 2 weeks. Patients were evaluated for wound healing on days 2, 3, 6-10, 14-16, and 28-30. The skin was swabbed for colonization at every visit to determine the quantity of bacteria throughout the healing process.
Ninety percent of patients in both groups experienced either "no pain" or "minimal pain" during the first 3 days. Total bacterial counts peaked on days 3 and 6 in the patients managed with the RRS and the Silon-TSR/Aquaphor regimen, respectively. The average day at which patients did not require a dressing was 3.0 days in the group managed with the RRS and 3.7 days in the group managed with the Silon-TSR/Aquaphor dressing regimen (P < or =.05). The average day of complete epithelial regeneration was significantly shorter at 6.3 days using the RRS compared with 7.4 days for patients using the Silon-TSR/Aquaphor regimen (P < or =.02). There was no difference in infection, adverse sequelae, exudate management, or pain in either group.
Healing was optimized in patients using the RRS after laser resurfacing.
激光换肤是一种改善光老化体征的常用方法。除了改进治疗方式外,优化术后护理方案将提高患者护理水平。
我们的目的是评估激光磨皮术后两种面部伤口护理方式的疗效。
42例患者在两家诊所接受全脸激光换肤,分别单独使用UltraPulse二氧化碳(CO₂)激光(相干激光公司,加利福尼亚州帕洛阿尔托),或之后使用铒:钇铝石榴石激光(Derma-20,ESC Sharplan公司,马萨诸塞州尼德姆)和/或混合CO₂/铒:钇铝石榴石激光(Derma-K,ESC Sharplan)或可变脉冲铒:钇铝石榴石激光(Contour,Sciton激光公司,加利福尼亚州帕洛阿尔托)。21例患者被随机分配到术后护理方案组,在激光换肤后的头2至3天使用Silon-TSR(生物医学科学公司,宾夕法尼亚州阿伦敦),之后使用凡士林软膏(拜尔斯道夫公司,北卡罗来纳州夏洛特)完成前2周护理。另外21例患者按照特定方案使用换肤恢复系统(RRS,露得清公司,加利福尼亚州洛杉矶)。该系统包括使用2天的纤维胶原伤口敷料(强生公司,新泽西州斯基尔曼),之后使用1至2天的水凝胶敷料,再之后使用软膏完成前2周护理。在术后第2、3、6 - 10、14 - 16和28 - 30天对患者的伤口愈合情况进行评估。每次就诊时对皮肤进行擦拭取样以确定整个愈合过程中的细菌数量。
两组中90%的患者在头3天经历“无痛”或“轻微疼痛”。使用RRS和Silon-TSR/凡士林软膏护理方案的患者,细菌总数分别在术后第3天和第6天达到峰值。使用RRS护理的患者平均不需要敷料的天数为3.0天,使用Silon-TSR/凡士林软膏护理方案的患者为3.7天(P≤0.05)。使用RRS的患者完全上皮再生的平均天数显著较短,为6.3天,而使用Silon-TSR/凡士林软膏护理方案的患者为7.4天(P≤0.02)。两组在感染、不良后遗症、渗出物处理或疼痛方面均无差异。
激光换肤后使用RRS的患者愈合情况得到优化。