Angra Kunal, Lipp Michael B, Sekhon Sahil, Wu Douglas C, Goldman Mitchel P
Drs. Angra, Lipp, Wu, and Goldman are with Cosmetic Laser Dermatology in San Diego, California.
Dr. Sekhon is with the Department of Dermatology at Howard University Hospital in Washington DC.
J Clin Aesthet Dermatol. 2021 Aug;14(8):24-32. Epub 2021 Aug 1.
Laser resurfacing produces a controlled skin injury, resulting in a wound healing response. This wound healing response allows for collagen remodeling, which improves skin texture and tone. Topical agents are often employed following laser treatments to facilitate recovery. The introduction of newer small-molecule technologies allow for improved recovery and cosmesis.
We sought to perform a critical review of the safety and efficacy of newer small-molecule technologies employed following laser resurfacing.
We performed a PubMed search of the generic name of the following topicals and included literature relevant to laser procedures, with an emphasis on laser resurfacing: thermal spring water, conjugated linolenic acid, vitamin C/vitamin E/ferulic acid serum, tripeptide/hexapeptide technology-containing products, growth factor serum and gel, recombinant human epidermal growth factor ointment and gel, red deer umbilical cord lining mesenchymal stem cell extract cream and serum, silicone-based gel, and microparticulate (1-3, 1-6 beta-glucan) gel.
Our search of the PubMed database yielded 62 results, out of which 17 clinical studies were included in this publication. The majority of aforementioned topicals show promise in terms of improving post-resurfacing recovery or cosmesis.
Clinical data regarding these agents is limited by the number and quality of studies. It is therefore challenging to propose a recommendation supporting any particular topical. We provide our own provider-specific post-laser resurfacing protocols to offer insight regarding new small-molecule technologies.
激光换肤会造成可控的皮肤损伤，引发伤口愈合反应。这种伤口愈合反应能促进胶原蛋白重塑，从而改善皮肤质地和色泽。激光治疗后常使用局部用药来促进恢复。更新的小分子技术的引入有助于改善恢复情况和美容效果。
我们试图对激光换肤后使用的更新的小分子技术的安全性和有效性进行批判性综述。
我们在PubMed上搜索了以下局部用药的通用名称，并纳入了与激光手术相关的文献，重点是激光换肤：温泉水、共轭亚麻酸、维生素C/维生素E/阿魏酸血清、含三肽/六肽技术的产品、生长因子血清和凝胶、重组人表皮生长因子软膏和凝胶、马鹿脐带衬里间充质干细胞提取物乳膏和血清、硅基凝胶以及微粒（1-3、1-6β-葡聚糖）凝胶。
我们在PubMed数据库中的搜索产生了62条结果，其中17项临床研究被纳入本出版物。上述大多数局部用药在改善换肤后的恢复情况或美容效果方面显示出前景。
关于这些药物的临床数据受研究数量和质量的限制。因此，提出支持任何特定局部用药的建议具有挑战性。我们提供了我们自己特定于医疗机构的激光换肤后方案，以提供有关新小分子技术的见解。
