Marrs Carl F, Zhang Lixin, Tallman Patricia, Manning Shannon D, Somsel Patricia, Raz Paul, Colodner Raul, Jantunen Maria E, Siitonen Anja, Saxen Harri, Foxman Betsy
Department of Epidemiology, University of Michigan School of Public Health, 109 Observatory Street, Ann Arbor, MI 48109, *Bureau of Laboratories, Michigan Department of Community Health, 3350 N. Martin Luther King Jr Blvd, PO Box 30035, Lansing, MI 48909, †Infectious Disease Unit and ‡Microbiology Laboratory, Ha'Emek Medical Center, 18101 Afula, Israel and †Faculty of Medicine, Technion, Haifa, Israel, §Hospital for Children and Adolescents, University of Helsinki and ∥Laboratory of Enteric Pathogens, National Public Health Institute, Mannerheimintie 166, FIN-00300, Helsinki, Finland.
J Med Microbiol. 2002 Feb;51(2):138-142. doi: 10.1099/0022-1317-51-2-138.
A total of 868 isolates was screened from seven different collections of organisms from previous studies - pyelonephritis in children aged 1-24 months; first, second and recurring urinary tract infection (UTI) in women aged 18-39 years; UTI in women aged 40-65 years and peri-urethral and faecal isolates from women aged 18-39 years - for the presence of 10 potential Escherichia coli UTI virulence genes. Previously reported differences between the frequency of these genes in UTI compared with faecal isolates were confirmed and extended. A single virulence signature (strains containing aer, kpsMT, ompT, fim and papGAD) occurred in 29% of the pyelonephritic isolates, but in no more than 11% of the other collections. Peri-urethral isolates were found to have frequencies of these 10 genes that differed from those found for both UTI and faecal isolates.
从先前研究的七个不同生物体样本集中筛选出总共868株分离菌，这些样本集包括：1至24个月大儿童的肾盂肾炎；18至39岁女性的首次、第二次及复发性尿路感染（UTI）；40至65岁女性的UTI以及18至39岁女性的尿道周围和粪便分离菌，以检测10种潜在的大肠杆菌UTI毒力基因的存在情况。先前报道的这些基因在UTI与粪便分离菌中的频率差异得到了证实并有所扩展。单一毒力特征（含有aer、kpsMT、ompT、fim和papGAD的菌株）出现在29%的肾盂肾炎分离菌中，但在其他样本集中的出现比例不超过11%。发现尿道周围分离菌中这10种基因的频率与UTI和粪便分离菌中的频率不同。
